{"id":"W2327242544","doi":"10.1093/neuonc/nou206.16","title":"SOX2 IDENTIFIES THE TREATMENT-REFRACTORY STEM CELL POPULATION IN GROUP 2 MEDULLOBLASTOMA","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Sonic hedgehog; Medulloblastoma; SOX2; Biology; Cancer research; Cancer stem cell; GLI1; Gene knockdown; Chromatin immunoprecipitation; Stem cell; Hedgehog signaling pathway; Signal transduction; Apoptosis; Transcription factor; Cell biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633272,0.0001904348,0.0003825754,0.0001475919,0.00009061607,0.00001860488,0.00008730329,0.0001430971,0.00007650411],"category_scores_gemma":[0.00003024882,0.0001200121,0.0001174185,0.0001548398,0.00006058253,0.00006360608,0.00002862951,0.0001510735,0.000140921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045113,"about_ca_system_score_gemma":0.00004019558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000306492,"about_ca_topic_score_gemma":0.001196439,"domain_scores_codex":[0.9985983,0.0003042728,0.0003113188,0.0003297171,0.0001739881,0.0002824269],"domain_scores_gemma":[0.9987152,0.0006561734,0.0001373776,0.0003649305,0.00002848694,0.00009787687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005221626,0.006977195,0.3662484,0.00006094606,0.0001221938,0.0007036637,0.002250513,0.00007100671,0.2985615,0.0007930876,0.003713351,0.3199759],"study_design_scores_gemma":[0.01138156,0.009689288,0.5643963,0.00004111512,0.0004031006,0.000148368,0.0006204375,0.0005703267,0.04703219,0.0002604054,0.365204,0.0002528401],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936121,0.0003163915,0.000005840937,0.002277384,0.0006591842,0.000566693,0.000003524985,0.00005483921,0.002504063],"genre_scores_gemma":[0.9983252,0.0001943437,0.00002908686,0.0009051141,0.0002024743,0.0001890726,0.00003313544,0.00002662995,0.00009499645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3614907,"threshold_uncertainty_score":0.4893953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709177097144906,"score_gpt":0.2793410073155154,"score_spread":0.2622492363440663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}