{"id":"W2327283214","doi":"10.1158/0008-5472.sabcs-09-706","title":"Biomarker Profiles in Trastuzumab (T) Refractory HER2+ Inflammatory Breast Cancer (IBC) That Predict for Survival Benefit from Lapatinib (L) Monotherapy.","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Medicine; Lapatinib; Internal medicine; Oncology; Trastuzumab; Cohort; Biomarker; Breast cancer; Cancer; Immunohistochemistry; Progression-free survival; Overall survival; Proportional hazards model; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667911,0.000158425,0.0002527926,0.0003238555,0.0001114583,0.0002661095,0.00009085531,0.0002508099,0.0008329652],"category_scores_gemma":[0.0007292621,0.00007671738,0.0001397505,0.0003492789,0.0001307474,0.000160878,0.0001354899,0.0002605136,0.000156024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554849,"about_ca_system_score_gemma":0.0001320168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006184693,"about_ca_topic_score_gemma":0.0007467417,"domain_scores_codex":[0.9999151,0.00002042239,0.00001032131,0.00001839998,0.00001718754,0.00001853738],"domain_scores_gemma":[0.9996465,0.00007083817,0.0001830047,0.00001149063,0.00002058524,0.00006745567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003606583,0.0001864876,0.9689624,0.00002936074,0.00005638673,0.0003734361,0.00006056883,0.0003904618,0.01611043,0.0000208921,0.0002123857,0.009990623],"study_design_scores_gemma":[0.0000486617,0.0009444528,0.9950703,0.000004102432,0.00003393281,0.0008800708,0.00004092309,0.0009559987,0.00173604,0.0000329076,0.0002492281,0.000003407918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994895,0.0001874361,0.00006669435,0.00001612677,0.000001316374,0.000005813056,0.00009852219,0.000002497543,0.0001320243],"genre_scores_gemma":[0.9996049,0.00003693293,0.00009488178,0.00001820441,0.000002739858,0.000004972061,0.0001725613,7.375227e-7,0.0000641189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008329652,"threshold_uncertainty_score":0.002786577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1319162603715293,"score_gpt":0.4425371703677506,"score_spread":0.3106209099962213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}