{"id":"W2327344211","doi":"10.1021/bi501526s","title":"Mode of Binding of the Cyclic Agonist Peptide TC14012 to CXCR7: Identification of Receptor and Compound Determinants","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Pharmacophore; Transmembrane domain; Chemistry; Receptor; Peptide; Agonist; G protein-coupled receptor; Chemokine receptor; Transmembrane protein; Biophysics; Chemotaxis; Stereochemistry; Biochemistry; Chemokine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016437,0.000400175,0.0004271564,0.0001421664,0.0001264436,0.0003181412,0.000492192,0.0003271455,0.00210046],"category_scores_gemma":[0.0001860119,0.0002056971,0.0002800182,0.0001108204,0.0002018275,0.0002310385,0.0001580154,0.0004231968,0.0006203605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796502,"about_ca_system_score_gemma":0.0002751382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008744656,"about_ca_topic_score_gemma":0.0006324475,"domain_scores_codex":[0.9998765,0.00002390892,0.000006745352,0.00002584414,0.00003461688,0.00003233628],"domain_scores_gemma":[0.9999344,0.00001859402,0.00001449729,0.000006612475,0.00001339398,0.0000124691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005424482,0.00007592771,0.0005133527,0.0001426097,0.00002124584,0.000267443,0.00005053541,0.003554578,0.9869955,0.0008712966,0.0003046556,0.006660427],"study_design_scores_gemma":[0.0001194807,0.001864817,0.001785037,0.00001409122,0.00004881511,0.0009973514,0.00006059741,0.01675116,0.9735444,0.0002795052,0.004491391,0.00004333569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830486,0.002281647,0.007865981,0.0001702646,0.00003798261,0.0001624917,0.0005686996,0.0001542225,0.005710212],"genre_scores_gemma":[0.9879299,0.00137559,0.007337481,0.0001123959,0.00001196205,0.00006679238,0.0004866388,0.00003625843,0.002642902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00210046,"threshold_uncertainty_score":0.007026792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299584204084166,"score_gpt":0.2970346873026838,"score_spread":0.2740388452618422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}