{"id":"W2327344211","doi":"10.1021/bi501526s","title":"Mode of Binding of the Cyclic Agonist Peptide TC14012 to CXCR7: Identification of Receptor and Compound Determinants","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Pharmacophore; Transmembrane domain; Chemistry; Receptor; Peptide; Agonist; G protein-coupled receptor; Chemokine receptor; Transmembrane protein; Biophysics; Chemotaxis; Stereochemistry; Biochemistry; Chemokine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591552,0.00008096942,0.0002285289,0.00002802462,0.00002182805,0.000004892522,0.00009582788,0.00006797261,0.00001009555],"category_scores_gemma":[0.0001928665,0.00006266232,0.00005950771,0.0001326713,0.0001021286,0.00001764809,0.00006191302,0.00005657531,0.000001278959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004001588,"about_ca_system_score_gemma":0.0000862581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003953449,"about_ca_topic_score_gemma":0.000001484581,"domain_scores_codex":[0.999198,0.0000101332,0.0003549955,0.0001387941,0.0002076547,0.00009042658],"domain_scores_gemma":[0.9992518,0.00002650619,0.0002390485,0.000261376,0.0001305859,0.00009070986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000519917,0.00005316376,0.02914253,0.000302448,0.00001480671,2.639134e-7,0.0002849502,0.000002289136,0.9691539,0.000002360917,0.0005672261,0.000423999],"study_design_scores_gemma":[0.0003934149,0.00002979019,0.001690259,0.0002889196,0.00004142179,0.00001202732,0.0003597896,0.0001128244,0.996839,0.000009474275,0.0001662414,0.00005681846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992142,0.0001395655,0.00002476683,0.00009440281,0.00007191689,0.0001173492,0.00003595078,0.000005276208,0.0002965338],"genre_scores_gemma":[0.9989702,0.00001133215,0.0003355622,0.000009077917,0.00006224147,0.000003268028,0.00001393938,0.000009676276,0.0005847185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02768505,"threshold_uncertainty_score":0.2555295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299584204084166,"score_gpt":0.2970346873026838,"score_spread":0.2740388452618422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}