{"id":"W2327349716","doi":"10.1021/np500158q","title":"Total Synthesis and Antibacterial Testing of the A54556 Cyclic Acyldepsipeptides Isolated from <i>Streptomyces hawaiiensis</i>","year":2014,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Depsipeptide; Chemistry; Stereochemistry; Antibacterial activity; Amide; Amine gas treating; Streptomyces; Hydrogenolysis; Peptide bond; Antibacterial agent; Cyclic peptide; Combinatorial chemistry; Organic chemistry; Antibiotics; Bacteria; Peptide; Biochemistry; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149096,0.0005982866,0.0002459569,0.000208685,0.0001457796,0.0001575693,0.0001651358,0.0001435854,0.0008441942],"category_scores_gemma":[0.0001202362,0.00008682442,0.0001767984,0.0003188842,0.0001111994,0.0001293202,0.0001698991,0.0002325504,0.0003110879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001309087,"about_ca_system_score_gemma":0.0002906309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008312564,"about_ca_topic_score_gemma":0.001343891,"domain_scores_codex":[0.9998941,0.00001724111,0.00001536045,0.00001920234,0.00003513863,0.00001885399],"domain_scores_gemma":[0.9999011,0.00001142905,0.00002201473,0.00001220399,0.00002861274,0.00002469703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004875813,0.00001909662,0.0001178218,0.00008495674,0.000007199896,0.00006272394,0.00001155711,0.00008907212,0.9945523,0.00003063978,0.00002153951,0.004954281],"study_design_scores_gemma":[0.00001231843,0.001079495,0.00264285,0.00001085725,0.00003669198,0.0001982678,0.00002738914,0.0002009377,0.9913577,0.00002143188,0.004404764,0.000007399092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808297,0.003283468,0.007583786,0.00003295864,0.00003147771,0.0002157159,0.001617217,0.00008817844,0.006317499],"genre_scores_gemma":[0.9802921,0.002488796,0.01261677,0.00003224042,0.00001270054,0.0001229536,0.002070946,0.00002560221,0.002337768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008441942,"threshold_uncertainty_score":0.002824068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006169687535723001,"score_gpt":0.2008127585951947,"score_spread":0.1946430710594717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}