{"id":"W2327349716","doi":"10.1021/np500158q","title":"Total Synthesis and Antibacterial Testing of the A54556 Cyclic Acyldepsipeptides Isolated from <i>Streptomyces hawaiiensis</i>","year":2014,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Depsipeptide; Chemistry; Stereochemistry; Antibacterial activity; Amide; Amine gas treating; Streptomyces; Hydrogenolysis; Peptide bond; Antibacterial agent; Cyclic peptide; Combinatorial chemistry; Organic chemistry; Antibiotics; Bacteria; Peptide; Biochemistry; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002443407,0.0001301827,0.0002876737,0.00002786827,0.00006327609,0.00002936807,0.000201955,0.0001103565,0.000005249655],"category_scores_gemma":[0.004136892,0.00007729029,0.0001411646,0.0001494735,0.0001110853,0.00001230335,0.0001154307,0.0001911763,4.032678e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006242209,"about_ca_system_score_gemma":0.00003051441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003007153,"about_ca_topic_score_gemma":0.000003605927,"domain_scores_codex":[0.9990209,0.00009408144,0.0003737788,0.0002065468,0.0001691262,0.0001355091],"domain_scores_gemma":[0.9988113,0.0001791311,0.00049044,0.0002260188,0.0002472568,0.00004584206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007586169,0.00003040604,0.006965554,0.00001412578,0.0001121065,7.017403e-7,0.00001318883,0.000005177386,0.9829002,0.000001036346,0.0003820039,0.009499641],"study_design_scores_gemma":[0.0001829934,0.00006713328,0.02720623,0.00009647418,0.0001264615,0.00004729702,0.00001794102,0.00005826101,0.9711565,0.00003593579,0.0009042203,0.0001005715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978477,0.0009485381,0.000005963241,0.0008635213,0.0002317083,0.0000387308,0.000008257922,0.000002719529,0.00005291099],"genre_scores_gemma":[0.9978785,0.00005795952,0.001057335,0.0000755214,0.0008780076,3.530683e-7,0.000003072301,0.00001055409,0.00003870351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02024068,"threshold_uncertainty_score":0.4952545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006169687535723001,"score_gpt":0.2008127585951947,"score_spread":0.1946430710594717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}