{"id":"W2327378428","doi":"10.3727/096368912x638964","title":"Human Neural Stem Cells Genetically Modified to Express Human Nerve Growth Factor (NGF) Gene Restore Cognition in the Mouse with Ibotenic Acid-Induced Cognitive Dysfunction","year":2012,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Ibotenic acid; Nerve growth factor; Cholinergic neuron; Neuroscience; Basal forebrain; Neural stem cell; Morris water navigation task; Cholinergic; Biology; Cognition; Cell biology; Stem cell; Central nervous system; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155173,0.0002814776,0.0001805985,0.0001781947,0.000446425,0.0001111108,0.00020982,0.0001477065,0.00002134892],"category_scores_gemma":[0.000005766226,0.0002098661,0.00006396774,0.0002819782,0.00006962459,0.0005702537,0.000010508,0.0002849647,0.00003762716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004715368,"about_ca_system_score_gemma":0.00001913181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003855105,"about_ca_topic_score_gemma":0.00008306088,"domain_scores_codex":[0.9976446,0.0006053358,0.0003672831,0.0004836869,0.0004666841,0.0004324131],"domain_scores_gemma":[0.9993185,0.0001157308,0.0001399531,0.0001970783,0.00008871727,0.0001399737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003224356,0.0002214434,0.0003799723,0.00008153498,0.000004640547,0.00002183993,0.003782765,0.0003127739,0.9944915,0.0001904007,0.000009725762,0.0001809483],"study_design_scores_gemma":[0.001394781,0.0005604975,0.01258909,0.00004204506,0.00009477804,0.00002302083,0.0002509641,0.0001189738,0.9846012,0.00002298805,0.000001914254,0.0002997639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922358,0.0000142988,0.005816182,0.0000641669,0.0002022703,0.001113985,0.0001206602,0.00007910417,0.0003535634],"genre_scores_gemma":[0.9987157,0.000014372,0.00006866182,0.0004383482,0.0002188895,0.0001827867,0.0001790599,0.00004027356,0.0001419308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01220912,"threshold_uncertainty_score":0.8558092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0611528902248616,"score_gpt":0.2727455681857574,"score_spread":0.2115926779608958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}