{"id":"W2327379756","doi":"10.1021/ja4082233","title":"Iron(II) Complexes Containing Unsymmetrical P–N–P′ Pincer Ligands for the Catalytic Asymmetric Hydrogenation of Ketones and Imines","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":300,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Enantiopure drug; Medicinal chemistry; Hydride; Imine; Catalysis; Ligand (biochemistry); Enantiomeric excess; Amide; Pincer movement; Amine gas treating; Transfer hydrogenation; Pincer ligand; Asymmetric hydrogenation; Organic chemistry; Ruthenium; Enantioselective synthesis; Hydrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006756191,0.0001748711,0.0005113818,0.00008263555,0.0002320158,0.00003022296,0.0005484099,0.00007652846,0.00001000355],"category_scores_gemma":[0.001472307,0.00009967654,0.0006733113,0.001318328,0.0005487573,0.00007978803,0.000185822,0.0002847651,4.004426e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001242327,"about_ca_system_score_gemma":0.00005693726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004571831,"about_ca_topic_score_gemma":8.316589e-7,"domain_scores_codex":[0.99843,0.00001820488,0.0006150832,0.0001741182,0.0005367224,0.0002258294],"domain_scores_gemma":[0.9963287,0.001698495,0.001306091,0.0002620368,0.0002980066,0.0001067284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000315081,0.0004556883,0.01888901,0.0002535864,0.001495606,6.123769e-7,0.001681156,0.0002770948,0.8216389,0.000821005,0.00734548,0.1468267],"study_design_scores_gemma":[0.001321168,0.0001494656,0.0016054,0.000041376,0.000621544,0.00005730205,0.001587531,0.01475842,0.9739156,0.0003720821,0.005343011,0.0002270688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946327,0.0007838615,0.001919371,0.002221607,0.00005711785,0.00007107021,0.00001594015,0.00001156615,0.0002867713],"genre_scores_gemma":[0.9982389,0.0001854492,0.0006899423,0.0004696456,0.0003000807,0.000006238003,0.000005617242,0.0000198807,0.00008427774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1522767,"threshold_uncertainty_score":0.4064691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201066670437195,"score_gpt":0.2563649990454375,"score_spread":0.2443543323410655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}