{"id":"W2327401507","doi":"10.1038/sj.cgt.7700145","title":"A novel, long-circulating, and functional liposomal formulation of antisense oligodeoxynucleotides targeted against MDR1","year":2000,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Liposome; Cationic liposome; In vivo; Biodistribution; Cationic polymerization; Pharmacokinetics; Biophysics; Chemistry; Drug carrier; In vitro; Pharmacology; Biochemistry; Biology; Transfection; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886134,0.0003149453,0.0002326813,0.0001255066,0.0001435005,0.0002809581,0.00024109,0.0003154826,0.0008232241],"category_scores_gemma":[0.0001429264,0.0001399022,0.0001027178,0.00007172081,0.0001894452,0.0003285814,0.0002037476,0.0005274598,0.0002769589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273175,"about_ca_system_score_gemma":0.0002529692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003669534,"about_ca_topic_score_gemma":0.0005969779,"domain_scores_codex":[0.9999433,0.000009472982,0.000004413188,0.00001669983,0.00001481741,0.00001141914],"domain_scores_gemma":[0.999935,0.00001179449,0.00001910383,0.000004389387,0.00001082575,0.00001889553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009321997,0.00003063754,0.00003932315,0.00003897291,0.00000300032,0.00005014492,0.0000121456,0.00009164301,0.9937972,0.0003994584,0.00008298925,0.005361367],"study_design_scores_gemma":[0.0000981756,0.0007042493,0.0003861366,0.000005788697,0.00002533883,0.0003585287,0.000007912814,0.001581055,0.9899716,0.00007341102,0.006777348,0.00001035583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9264082,0.004359524,0.06414689,0.0005663399,0.0001725084,0.0002387538,0.0002713934,0.0003670142,0.003469415],"genre_scores_gemma":[0.9683954,0.001487188,0.02363751,0.0001668543,0.00004286896,0.0001307879,0.0002515019,0.00004916704,0.005838689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008232241,"threshold_uncertainty_score":0.002753973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827905167015242,"score_gpt":0.2498788672408819,"score_spread":0.2315998155707295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}