{"id":"W2327409223","doi":"10.1021/jp5111357","title":"Distinct Helix Propensities and Membrane Interactions of Human and Rat IAPP<sub>1–19</sub> Monomers in Anionic Lipid Bilayers","year":2015,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canada Research Chairs","keywords":"Chemistry; Membrane; Amylin; Lipid bilayer; Peptide; Helix (gastropod); Biophysics; Amphiphile; Random coil; Crystallography; Monomer; Bilayer; Molecular dynamics; Amyloid (mycology); Islet; Biochemistry; Circular dichroism; Copolymer; Computational chemistry; Insulin; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133278,0.0002653105,0.0002099984,0.0001826586,0.0003751989,0.0003184224,0.0002544246,0.0002539486,0.001084289],"category_scores_gemma":[0.0003827744,0.0001906264,0.0002672824,0.0001509881,0.0003759413,0.0004218402,0.0002405559,0.0005007404,0.0002063259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000452141,"about_ca_system_score_gemma":0.0003176139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003683122,"about_ca_topic_score_gemma":0.001906439,"domain_scores_codex":[0.9999387,0.000009531616,0.000002891192,0.00001354176,0.00001613101,0.00001923035],"domain_scores_gemma":[0.9999033,0.00002615218,0.00002385206,0.000005207521,0.000015215,0.00002625724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001134266,0.0001864704,0.009662779,0.0002300462,0.0001664224,0.000757791,0.0008723955,0.09683393,0.879716,0.004141794,0.0005013534,0.005796752],"study_design_scores_gemma":[0.0003524724,0.001357131,0.03614651,0.0001066723,0.0001847886,0.0004823144,0.001585428,0.5447024,0.4089966,0.003057177,0.002840932,0.0001875876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988977,0.0001319433,0.0003344351,0.00002737501,0.000003321121,0.000003168836,0.00006114535,0.00001690126,0.0005240896],"genre_scores_gemma":[0.9990841,0.0001741559,0.0003891992,0.00001759,0.000001489512,0.000006780268,0.0001554372,0.00001233503,0.0001588352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003683122,"threshold_uncertainty_score":0.007323384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095121042644566,"score_gpt":0.2513582333693012,"score_spread":0.2404070229428555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}