{"id":"W2327419046","doi":"10.1097/md.0000000000002697","title":"Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes","year":2016,"lang":"en","type":"article","venue":"Medicine","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"China Pharmaceutical University; National Natural Science Foundation of China","keywords":"KRAS; Synthetic lethality; Cancer; Gene; Cancer research; Mutation; Phenotype; Malignancy; Cancer cell; Medicine; Biology; Genetics; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004450939,0.0000537909,0.0001001018,0.0000315176,0.00002246239,6.845112e-7,0.00004156648,0.00002616316,0.00009951115],"category_scores_gemma":[0.00004300326,0.00003129415,0.00001430626,0.00006349802,0.0002491215,0.000002537737,0.00001003975,0.0000164354,2.135936e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001887785,"about_ca_system_score_gemma":0.0000674786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003815482,"about_ca_topic_score_gemma":0.0006322908,"domain_scores_codex":[0.9996192,0.00001702687,0.0001201242,0.0001127488,0.00006646499,0.0000644177],"domain_scores_gemma":[0.9996043,0.000020365,0.0001046178,0.000118614,0.0001253277,0.00002678665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002519038,0.00001851733,0.01771595,0.00001125993,0.00009673974,4.83074e-7,0.0001328862,0.00002499055,0.96512,0.0001033271,0.0003099255,0.0164407],"study_design_scores_gemma":[0.002687352,0.0007975244,0.2116074,0.001242667,0.0003060265,0.00001311272,0.0006633291,0.00004269475,0.7684541,0.0001318018,0.01381793,0.0002360585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954006,0.001895875,0.0009184788,0.001009988,0.0000620135,0.0000667973,0.00004824656,0.000002525368,0.0005954889],"genre_scores_gemma":[0.9977313,0.0009149445,0.00005039563,0.00002590769,0.00004376675,0.00003056289,0.00001228983,0.000006638262,0.001184255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1966659,"threshold_uncertainty_score":0.1276138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212063118639086,"score_gpt":0.2796637882184125,"score_spread":0.2675431570320217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}