{"id":"W2327499000","doi":"10.1021/es503399r","title":"Photolytic Degradation Products of Two Highly Brominated Flame Retardants Cause Cytotoxicity and mRNA Expression Alterations in Chicken Embryonic Hepatocytes","year":2014,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Ontario Genomics; University of Ottawa; Carleton University; Environment and Climate Change Canada","funders":"State Administration of Foreign Experts Affairs; Chinese Academy of Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Cytotoxicity; Degradation (telecommunications); Embryonic stem cell; Chemistry; Messenger RNA; Brominated flame retardant; Cell biology; Fire retardant; Molecular biology; Biophysics; Environmental chemistry; Biochemistry; Biology; Organic chemistry; Gene; In vitro; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005842533,0.0002047869,0.0001389404,0.0001474238,0.00009109875,0.0001709849,0.0000705073,0.000143298,0.0007280039],"category_scores_gemma":[0.00006487165,0.0001438138,0.0001715169,0.000102371,0.000149932,0.00008012712,0.00008359866,0.0001727125,0.0002024081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805015,"about_ca_system_score_gemma":0.0001229113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235105,"about_ca_topic_score_gemma":0.002237597,"domain_scores_codex":[0.9999173,0.000006943567,0.000007347583,0.00003533691,0.00001925762,0.000013751],"domain_scores_gemma":[0.9999363,0.00001446224,0.00001970317,0.000006727202,0.00001445648,0.000008343898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004563918,0.000003177548,0.0003046586,0.00001261382,0.000001903899,0.00001356704,0.000008790596,0.00001785748,0.9993103,0.000007690589,0.000005976877,0.0002679235],"study_design_scores_gemma":[0.000004865424,0.0001890998,0.02290202,0.00000291694,0.00001509714,0.0001035726,0.00005456132,0.0002064831,0.9758459,0.00001235977,0.0006600812,0.000002987221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962882,0.0007845699,0.001530599,0.00002372793,0.0000112618,0.00001249305,0.0005777147,0.00002905893,0.0007422366],"genre_scores_gemma":[0.9900773,0.001136076,0.002342557,0.00005725997,0.000005681261,0.00006193481,0.001464977,0.0000177236,0.004836499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235105,"threshold_uncertainty_score":0.00245589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007231034206305197,"score_gpt":0.2246729361512929,"score_spread":0.2174419019449877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}