{"id":"W2327509943","doi":"10.1021/ac101949s","title":"A Sol−Gel-Derived Acetylcholinesterase Microarray for Nanovolume Small-Molecule Screening","year":2010,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Innovation Trust","keywords":"Chemistry; Chromatography; Acetylthiocholine; Acetylcholinesterase; Fluorescence; Rhodamine; Sol-gel; Combinatorial chemistry; Enzyme; Nanotechnology; Biochemistry; Aché","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009558217,0.0001951152,0.0001596292,0.00001255801,0.0001311682,0.00003921186,0.000243444,0.0002796066,0.00002285738],"category_scores_gemma":[0.000186037,0.0001923114,0.000176701,0.00006781579,0.0001568863,0.000003072748,0.000108532,0.0002063156,0.000004046618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006591294,"about_ca_system_score_gemma":0.00004769076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004298815,"about_ca_topic_score_gemma":0.00001052236,"domain_scores_codex":[0.9989001,0.00000575198,0.0002226085,0.0004803701,0.00007110729,0.0003201072],"domain_scores_gemma":[0.9990593,0.00002003254,0.00007430516,0.0005346561,0.0001521203,0.0001595485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003915369,0.00005473636,0.00008107472,0.00002060152,0.00002612666,0.000001425581,0.000003119289,0.000002524712,0.996736,0.00004048481,0.002223856,0.0007708212],"study_design_scores_gemma":[0.000372808,0.00002396306,0.00002883629,0.000009622571,0.00003270321,0.00002939694,0.00001156028,0.0006540016,0.9280421,0.0000764935,0.07047354,0.0002449526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.855677,0.00004054813,0.1421203,0.0008129634,0.00003060621,0.0002129868,0.00005020247,0.00006856703,0.0009868037],"genre_scores_gemma":[0.9134729,0.0000149618,0.08145529,0.000637182,0.0005088163,0.00006580218,0.0004193961,0.00004342702,0.003382263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06869396,"threshold_uncertainty_score":0.7842233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492708924348537,"score_gpt":0.2858604210380302,"score_spread":0.2709333317945449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}