{"id":"W2327540272","doi":"10.1021/bi201853n","title":"Sequence Hydropathy Dominates Membrane Protein Response to Detergent Solubilization","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Circular dichroism; Chemistry; Sodium dodecyl sulfate; Membrane protein; Biochemistry; Peptide sequence; Protein secondary structure; Transmembrane protein; Membrane; Transmembrane domain; Biophysics; Gel electrophoresis; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837243,0.0002088188,0.0002580408,0.0001099734,0.00009807031,0.0002381985,0.00008400525,0.0002056696,0.0006039557],"category_scores_gemma":[0.0004536936,0.0001333882,0.00013931,0.00008576029,0.0002873018,0.0002542436,0.0001780077,0.000300133,0.0001645988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559675,"about_ca_system_score_gemma":0.0001275708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693461,"about_ca_topic_score_gemma":0.0003343819,"domain_scores_codex":[0.9997981,0.00004225747,0.00001633651,0.00003514323,0.00007289232,0.00003526927],"domain_scores_gemma":[0.9996738,0.00008718601,0.0001161207,0.00002506968,0.00004816803,0.00004964333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003891361,0.000002818516,0.000483273,0.000007075985,0.000001864198,0.00001461414,0.000008528025,0.00003961083,0.9991677,0.000009412587,0.000001645408,0.0002244267],"study_design_scores_gemma":[0.000004732507,0.0002965679,0.01601171,0.000003120812,0.000005824493,0.0002254634,0.00004475563,0.0008646849,0.9822285,0.00005294713,0.0002574917,0.000004325135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991413,0.0002144454,0.0004340585,0.00001650816,0.000001494698,0.000005525361,0.00002513586,0.00001156431,0.0001498623],"genre_scores_gemma":[0.9991317,0.0001688413,0.0004314641,0.00002022996,0.000002136358,0.000005694636,0.00008619362,0.000004116749,0.0001496275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006039557,"threshold_uncertainty_score":0.002020419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164161547992889,"score_gpt":0.3209426773072863,"score_spread":0.2993010618273574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}