{"id":"W2327548993","doi":"10.1093/intimm/dxw017","title":"CpG-mediated augmentation of CD8+ T-cell responses in mice is attenuated by a water-in-oil emulsion (Montanide ISA-51) but enhanced by an oil-in-water emulsion (IDRI SE)","year":2016,"lang":"en","type":"article","venue":"International Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); Terry Fox Research Institute","funders":"Pfizer","keywords":"Adjuvant; Immunogenicity; TLR9; Squalene; CpG Oligodeoxynucleotide; Immunology; Immunity; Immune system; CD8; Medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005199343,0.0004068769,0.0005957871,0.0008218718,0.00008502154,0.00001902832,0.0006908377,0.0006370026,0.002131976],"category_scores_gemma":[0.0001465096,0.0002853587,0.000118408,0.0001913235,0.0003559765,0.0005512754,0.0001769675,0.0004422677,0.0006611684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074297,"about_ca_system_score_gemma":0.00004743153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003153668,"about_ca_topic_score_gemma":0.000335452,"domain_scores_codex":[0.996012,0.001216968,0.001230841,0.0006637634,0.0001300447,0.0007464298],"domain_scores_gemma":[0.9985418,0.0005606186,0.0002812976,0.0003974985,0.0001958208,0.00002293873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01475759,0.0009623879,0.001816068,0.00001307766,0.0001638558,0.00001800386,0.002948642,0.000002908962,0.9686006,0.000009629608,0.0004988912,0.0102084],"study_design_scores_gemma":[0.01082779,0.0006107059,0.003748859,0.0002165005,0.00001209545,0.00003866671,0.0006169229,0.00001217397,0.9719915,0.00007359152,0.01147805,0.0003730784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933519,0.002242542,0.0001027866,0.002467166,0.001101353,0.0001722999,0.0002566118,0.00005411085,0.0002511998],"genre_scores_gemma":[0.972302,0.002613788,0.00002422735,0.0003462805,0.00001351308,0.0001195154,0.001165348,0.00004775772,0.02336761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02311641,"threshold_uncertainty_score":0.9999599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009367075137197005,"score_gpt":0.2555511001150279,"score_spread":0.2461840249778309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}