{"id":"W2327552837","doi":"10.1006/mthe.2002.0679","title":"Feasibility of Using Autologous Transplantation to Evaluate Hematopoietic Stem Cell-Based Gene Therapy Strategies in Transgenic Mouse Models of Human Disease","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies; BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; National Center for Research Resources; U.S. Public Health Service","keywords":"Haematopoiesis; Stem cell; Biology; Genetic enhancement; Transgene; Bone marrow; Transplantation; Hematopoietic stem cell; Hematopoietic stem cell transplantation; Progenitor cell; Immunology; Genetically modified mouse; Cancer research; Medicine; Cell biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236722,0.0006287717,0.0003776186,0.0007505993,0.0002811425,0.0006952374,0.0003622394,0.0007024358,0.002771286],"category_scores_gemma":[0.0003295691,0.000231436,0.0003116107,0.0002607042,0.0004284643,0.0004226755,0.0002816989,0.001070815,0.0005853698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002594886,"about_ca_system_score_gemma":0.0003382881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000385071,"about_ca_topic_score_gemma":0.0005342973,"domain_scores_codex":[0.9993967,0.0001441276,0.00007704861,0.0001116178,0.0001946351,0.00007578756],"domain_scores_gemma":[0.9997222,0.00006180644,0.00007131919,0.00005498353,0.0000403078,0.00004950045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635282,0.0002245703,0.0003299541,0.00005564423,0.000009930613,0.0000467786,0.00003393442,0.0001743209,0.9963747,0.0004017532,0.0000701255,0.002114692],"study_design_scores_gemma":[0.00007377611,0.002815742,0.001878926,0.00002089821,0.00005130533,0.0003177982,0.00003905581,0.001884555,0.988829,0.0002018517,0.003878128,0.000009008657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9256206,0.00286703,0.06321625,0.0002421801,0.0002086769,0.001499768,0.001492187,0.0005889707,0.004264457],"genre_scores_gemma":[0.9565151,0.002105683,0.03444751,0.0001504293,0.00005497095,0.001335036,0.001118671,0.0001253832,0.004147273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002771286,"threshold_uncertainty_score":0.009270906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07726135612254657,"score_gpt":0.3424454420262714,"score_spread":0.2651840859037248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}