{"id":"W2327552837","doi":"10.1006/mthe.2002.0679","title":"Feasibility of Using Autologous Transplantation to Evaluate Hematopoietic Stem Cell-Based Gene Therapy Strategies in Transgenic Mouse Models of Human Disease","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies; BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; National Center for Research Resources; U.S. Public Health Service","keywords":"Haematopoiesis; Stem cell; Biology; Genetic enhancement; Transgene; Bone marrow; Transplantation; Hematopoietic stem cell; Hematopoietic stem cell transplantation; Progenitor cell; Immunology; Genetically modified mouse; Cancer research; Medicine; Cell biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004472347,0.00030023,0.000377401,0.0001987785,0.00005728321,0.00002002529,0.0003876148,0.0001511321,0.00005509848],"category_scores_gemma":[0.000002322263,0.0002960961,0.0002502511,0.0002966617,0.0001357236,0.00001268534,0.00001414472,0.0001136591,0.000001604928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004141534,"about_ca_system_score_gemma":0.0001831928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005073381,"about_ca_topic_score_gemma":0.00004702611,"domain_scores_codex":[0.99756,0.0005310623,0.0005279189,0.0005473046,0.0004490981,0.0003845717],"domain_scores_gemma":[0.9987621,0.0000144284,0.0001332391,0.0007795698,0.000158041,0.0001525712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003564118,0.0005630086,0.0003522832,0.00008755129,0.00005095589,0.00001112684,0.0005695518,0.1292568,0.8646525,0.00001257363,0.000001349043,0.0008781451],"study_design_scores_gemma":[0.003880693,0.002053324,0.0003239338,0.00002473811,0.00001740555,0.000001367321,0.00006781826,0.007072518,0.9859757,0.0003051433,0.000002454432,0.0002748739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801573,0.004333035,0.01423302,0.00005473074,0.00001779558,0.001087652,0.00006395648,0.00001640879,0.000036161],"genre_scores_gemma":[0.9983392,0.0008597408,0.000433911,0.0001444331,0.00001157301,0.00006650924,0.0000571753,0.00006461833,0.00002279333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1221843,"threshold_uncertainty_score":0.9999491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07726135612254657,"score_gpt":0.3424454420262714,"score_spread":0.2651840859037248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}