{"id":"W2327695277","doi":"10.1016/j.bmc.2016.03.056","title":"Tumour-specific cytotoxicity and structure–activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Ministry of Education, Culture, Sports, Science and Technology; University of Saskatchewan","keywords":"Chemistry; Cytotoxicity; Cytotoxic T cell; Melphalan; Stereochemistry; Structure–activity relationship; Apoptosis; In vitro; IC50; L1210 cells; Biochemistry; Pharmacology; Immunology; Multiple myeloma; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004825017,0.0004153998,0.0006390523,0.00003571399,0.0002034173,0.00002213035,0.0003744186,0.0005673388,0.002804239],"category_scores_gemma":[0.001785686,0.000257161,0.0001330241,0.0002061205,0.0006259999,0.0001432005,0.0001938178,0.0005404507,0.000005286053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550113,"about_ca_system_score_gemma":0.0001201914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004138135,"about_ca_topic_score_gemma":0.000006026431,"domain_scores_codex":[0.9977121,0.00006548804,0.0005212094,0.0007586697,0.0005065417,0.0004359262],"domain_scores_gemma":[0.997287,0.00128763,0.0004271956,0.000552212,0.000151563,0.0002943524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001533491,0.0002157311,0.01130121,0.0002248598,0.0000466663,0.000006652314,0.00004340152,9.163037e-8,0.9822326,0.00006360689,0.00008617732,0.005625693],"study_design_scores_gemma":[0.0009387354,0.00003383782,0.03741652,0.0002489949,0.00004755946,0.0000854988,0.0001541714,0.00001158181,0.9596269,0.000196457,0.0008883492,0.0003514252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955973,0.0007931176,0.0008992291,0.0008516863,0.0000768337,0.00008810739,0.0002296601,0.0001107347,0.001353301],"genre_scores_gemma":[0.9981605,0.0002562047,0.0005966038,0.00002631939,0.0005778007,0.000009676295,0.0000115264,0.00003384086,0.0003275393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02611531,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04570747406993783,"score_gpt":0.2412891545015284,"score_spread":0.1955816804315905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}