{"id":"W2327695277","doi":"10.1016/j.bmc.2016.03.056","title":"Tumour-specific cytotoxicity and structure–activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Ministry of Education, Culture, Sports, Science and Technology; University of Saskatchewan","keywords":"Chemistry; Cytotoxicity; Cytotoxic T cell; Melphalan; Stereochemistry; Structure–activity relationship; Apoptosis; In vitro; IC50; L1210 cells; Biochemistry; Pharmacology; Immunology; Multiple myeloma; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457841,0.0002274173,0.0001875072,0.0001694723,0.00008955312,0.000137033,0.0002213434,0.0001292401,0.001150018],"category_scores_gemma":[0.0001301915,0.0001169648,0.000160039,0.0001106108,0.0001211722,0.0001342544,0.0001235595,0.0003726338,0.0003451313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001880901,"about_ca_system_score_gemma":0.0001561191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005146816,"about_ca_topic_score_gemma":0.001303116,"domain_scores_codex":[0.9999467,0.0000119142,0.000006111696,0.00000905458,0.00001038758,0.00001586303],"domain_scores_gemma":[0.9999167,0.00002295301,0.00002044183,0.000008980832,0.0000113397,0.00001965465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004139174,0.0001519594,0.0002675045,0.00009108927,0.000008064596,0.00008391201,0.0000410707,0.0007129885,0.992419,0.0001773157,0.0001191577,0.005514085],"study_design_scores_gemma":[0.00008146255,0.002752128,0.004486324,0.000008801571,0.0000320441,0.0003026646,0.00001987513,0.001523618,0.9881753,0.00004731857,0.002562331,0.000008016115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932729,0.002506825,0.001598304,0.0000683246,0.00002268135,0.00002728175,0.0002989312,0.00006499286,0.002139586],"genre_scores_gemma":[0.9954086,0.001538175,0.0008303781,0.00002282491,0.000009815169,0.00002157354,0.0005028672,0.000008449222,0.001657281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150018,"threshold_uncertainty_score":0.003847182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04570747406993783,"score_gpt":0.2412891545015284,"score_spread":0.1955816804315905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}