{"id":"W2327719413","doi":"10.5588/ijtld.14.0405","title":"Serum drug concentrations of INH and RMP predict 2-month sputum culture results in tuberculosis patients","year":2015,"lang":"en","type":"article","venue":"The International Journal of Tuberculosis and Lung Disease","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Alberta Health; University of Alberta","funders":"","keywords":"Medicine; Sputum; Dosing; Sputum culture; Internal medicine; Tuberculosis; Retrospective cohort study; Rifampicin; Cmax; Diabetes mellitus; Population; Isoniazid; Cohort; Therapeutic drug monitoring; Gastroenterology; Pharmacokinetics; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001035696,0.0001616364,0.0003809411,0.0002064648,0.00004805588,0.00003931172,0.0002421829,0.00006332538,0.00001889699],"category_scores_gemma":[0.001891839,0.0001000353,0.0001394164,0.0001426725,0.0002046176,0.0002579789,0.0001319813,0.000345849,0.000001288204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014745,"about_ca_system_score_gemma":0.0002212174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002124134,"about_ca_topic_score_gemma":0.00007016436,"domain_scores_codex":[0.9977959,0.0002309404,0.0007858715,0.000196865,0.0007608777,0.0002295128],"domain_scores_gemma":[0.9978535,0.0002257485,0.0003061651,0.0001779789,0.0008498079,0.0005868531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00405769,0.000616979,0.9488013,0.00006425089,0.0006120659,0.00008390152,0.001625921,0.0002349261,0.0001778591,0.0003261958,0.04078774,0.00261118],"study_design_scores_gemma":[0.006182989,0.0003876612,0.982733,0.000454182,0.000323804,0.00007552825,0.0006371734,0.006407016,0.0001576904,0.0005174192,0.001998224,0.0001252855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639353,0.003492788,0.000008659912,0.0312774,0.000259654,0.0002695299,0.000245352,0.000005923934,0.0005053543],"genre_scores_gemma":[0.9959788,0.002406213,0.00008341749,0.001094699,0.0002603825,0.000007326574,0.00005903337,0.00001174174,0.00009836625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03878951,"threshold_uncertainty_score":0.4079321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558777234815009,"score_gpt":0.3054247075051955,"score_spread":0.2898369351570454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}