{"id":"W2327789875","doi":"10.1021/jm500857r","title":"Identification of<i>N</i>-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1<i>H</i>-indol-1-yl)acetyl]-<scp>l</scp>-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health","keywords":"Neurotensin; Chemistry; Sulfonyl; Chemical synthesis; Stereochemistry; Neurotensin receptor; Ligand (biochemistry); Receptor; Leucine; Pharmacology; Amino acid; Neuropeptide; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168654,0.0003800622,0.0003114348,0.0002735278,0.0001590787,0.0001211347,0.0003607666,0.0003491362,0.00314812],"category_scores_gemma":[0.0001952191,0.0001246505,0.0002114629,0.0001589649,0.0001772738,0.0002708107,0.0001783988,0.0002691094,0.0006056663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448766,"about_ca_system_score_gemma":0.0005215731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008586093,"about_ca_topic_score_gemma":0.001705271,"domain_scores_codex":[0.9999076,0.00001424013,0.000007517745,0.00001953057,0.00002066371,0.00003051902],"domain_scores_gemma":[0.9998776,0.00001592936,0.00003664359,0.000007715883,0.00003098119,0.00003113367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003219559,0.00007665435,0.0001713197,0.0001335848,0.000009007422,0.0002406029,0.00001852855,0.0001078258,0.9948546,0.0001585943,0.0001551806,0.003752191],"study_design_scores_gemma":[0.000149423,0.00283924,0.003114331,0.00001694447,0.00003439441,0.0007283071,0.00003191278,0.0006592834,0.9873218,0.00006715794,0.00502442,0.00001268123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784812,0.002800542,0.006793096,0.0002575516,0.0000727137,0.0003580179,0.00133076,0.0001153665,0.009790719],"genre_scores_gemma":[0.9762916,0.001902607,0.009980301,0.000236014,0.00003565648,0.0001616996,0.002349008,0.00003149384,0.009011598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00314812,"threshold_uncertainty_score":0.01053149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150365600506414,"score_gpt":0.2602078857002829,"score_spread":0.2387042296952188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}