{"id":"W2327790111","doi":"10.1021/bi2019018","title":"Intrinsically Disordered N-Terminus of Calponin Homology-Associated Smooth Muscle Protein (CHASM) Interacts with the Calponin Homology Domain to Enable Tropomyosin Binding","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Royal University; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Calponin; Tropomyosin; Chemistry; Homology (biology); Biophysics; Cell biology; Biochemistry; Biology; Actin; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008347486,0.0001561913,0.0001426447,0.00008664197,0.0001808904,0.0001134196,0.0001485845,0.0002126326,0.0005171585],"category_scores_gemma":[0.00015168,0.0000721916,0.0001977237,0.00009782001,0.0002273054,0.0001715256,0.0002062032,0.0003083825,0.0001791832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002255154,"about_ca_system_score_gemma":0.0001409719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000482112,"about_ca_topic_score_gemma":0.0008248043,"domain_scores_codex":[0.9999589,0.00000670495,0.000002163308,0.00001228036,0.0000109895,0.000009026824],"domain_scores_gemma":[0.9999046,0.00002213405,0.00003125143,0.000007484522,0.000008854146,0.0000257157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004444332,0.000009256191,0.0007835979,0.00002009522,0.00000485318,0.0001835156,0.00001521519,0.0001335462,0.9979553,0.0001616597,0.00002702004,0.0006614125],"study_design_scores_gemma":[0.00004372425,0.0003511401,0.04814152,0.00001557802,0.00002905375,0.002174648,0.0001400491,0.01122955,0.9316283,0.0007672962,0.005460777,0.00001828591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969504,0.0003493959,0.002251428,0.00004557012,0.000009038561,0.000005507381,0.00004778245,0.00001481035,0.0003260906],"genre_scores_gemma":[0.9963517,0.0001501881,0.002858045,0.0000443111,0.000006420741,0.000004947201,0.0001547806,0.000005012046,0.0004246772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005171585,"threshold_uncertainty_score":0.001730084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582405674039079,"score_gpt":0.2589761479526304,"score_spread":0.2431520912122396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}