{"id":"W2327795699","doi":"10.1021/cb500956g","title":"Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Wellcome Trust; Canadian Institutes of Health Research; Welch Foundation; National Cancer Institute; W. M. Keck Foundation","keywords":"Chromatin; DNA; Lysine; Ligand (biochemistry); Histone; Chemistry; Small molecule; Binding site; DNA repair; Biochemistry; Biology; Cell biology; Amino acid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004694379,0.0001396224,0.0001808922,0.00002975359,0.00003563842,0.00001000621,0.0003465499,0.0002548493,0.000002528781],"category_scores_gemma":[0.0005870513,0.0001030017,0.0001011901,0.0000963043,0.0001333811,0.000002444001,0.0001775055,0.00007513382,0.00000737926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001811806,"about_ca_system_score_gemma":0.00005964145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008818284,"about_ca_topic_score_gemma":0.000002446425,"domain_scores_codex":[0.9989692,0.00005053577,0.0003162473,0.0003551484,0.00007133935,0.0002375223],"domain_scores_gemma":[0.9990857,0.00004873239,0.0001839147,0.0004273018,0.0001835595,0.00007075263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211064,0.00005099757,0.0000399048,0.00001575152,0.00008253093,2.375098e-7,0.00002518722,0.000001530433,0.9977328,0.0004428324,0.0004214108,0.001065681],"study_design_scores_gemma":[0.0006188608,0.0002328346,0.000002429841,0.000005598627,0.00004156142,0.000004587859,0.00005395783,0.00008242355,0.9927746,0.0008671799,0.005194953,0.0001210104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876024,0.0005352668,0.01067116,0.0003663518,0.0001490643,0.0005635621,0.00003717263,0.0000161639,0.00005893375],"genre_scores_gemma":[0.9968909,0.00002460627,0.001848234,0.000139404,0.0001391334,0.0002266422,0.0002460608,0.00002073024,0.0004642877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009288577,"threshold_uncertainty_score":0.4200287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02155426413381518,"score_gpt":0.269360545872288,"score_spread":0.2478062817384728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}