{"id":"W2327826156","doi":"10.1021/acs.inorgchem.5b00554","title":"Nitroimidazole-Containing H<sub>2</sub>dedpa and H<sub>2</sub><i>CHX</i>dedpa Derivatives as Potential PET Imaging Agents of Hypoxia with <sup>68</sup>Ga","year":2015,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordion (Canada); University of British Columbia; BC Cancer Agency; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canada Council for the Arts","keywords":"Chemistry; Chelation; In vivo; Imaging agent; Nitroimidazole; In vitro; SKBR3; Pet imaging; Stereochemistry; Nuclear chemistry; Radiochemistry; Positron emission tomography; Cancer cell; Biochemistry; Cancer; Nuclear medicine; Organic chemistry; Human breast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005941906,0.0001714137,0.000143307,0.00005826992,0.0000734418,0.0001043819,0.0002970395,0.0001990515,0.0006045031],"category_scores_gemma":[0.00009508149,0.0001003465,0.00007095915,0.0001114931,0.0001620583,0.0001204423,0.0000942207,0.0002210285,0.0001249377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374758,"about_ca_system_score_gemma":0.0001388144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211269,"about_ca_topic_score_gemma":0.002918213,"domain_scores_codex":[0.9999616,0.000005864949,0.000002497993,0.000008388703,0.00001249171,0.000009072746],"domain_scores_gemma":[0.9999588,0.000007000966,0.00001286499,0.000004120777,0.000009152062,0.000008107829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007522969,0.00001135751,0.0001216504,0.0000433752,0.000002463595,0.00005853695,0.00001980497,0.0001153521,0.997792,0.00008818735,0.00003186362,0.001640167],"study_design_scores_gemma":[0.00001000124,0.0002094205,0.00139197,0.000002829039,0.000008001951,0.0001975566,0.00001394251,0.00052297,0.9951277,0.00001138273,0.002500389,0.000003906022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928082,0.001894644,0.002880395,0.00004658996,0.000007678116,0.00003191889,0.0001291791,0.00004656252,0.002154821],"genre_scores_gemma":[0.9907063,0.001066035,0.004965054,0.00004400015,0.000003914191,0.00003391496,0.0002539976,0.00001258521,0.002914313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211269,"threshold_uncertainty_score":0.002408445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158405782794552,"score_gpt":0.2586280855398868,"score_spread":0.2427875072604316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}