{"id":"W2327911874","doi":"10.1038/sj.cgt.7700195","title":"Combinational immunotherapy for established tumors with engineered tumor vaccines and adenovirus-mediated gene transfer","year":2000,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Medical Research Council","keywords":"Immunogenicity; Tumor necrosis factor alpha; Immunotherapy; CD8; Cancer research; Genetic enhancement; Cytotoxic T cell; Immune system; Cytokine; Biology; Immunology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002211029,0.0003370857,0.0002978445,0.00009453008,0.0001567175,0.00006034943,0.0002966589,0.0001125607,0.000756453],"category_scores_gemma":[0.00000659846,0.0002846007,0.00009251453,0.0002263814,0.0001147573,0.0000151107,0.00001015161,0.0001153474,0.000004713886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003782835,"about_ca_system_score_gemma":0.0003029369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003295838,"about_ca_topic_score_gemma":0.00008843114,"domain_scores_codex":[0.998395,0.00007272779,0.0002599644,0.0005512708,0.0002465174,0.0004745372],"domain_scores_gemma":[0.9991822,0.00003596607,0.00003701412,0.0003960271,0.0002052352,0.000143505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01222805,0.0001227611,0.0004012646,0.00001326401,0.0003044324,0.000003502113,0.0001364829,0.0005629829,0.9507113,0.000006117622,0.0003618541,0.03514797],"study_design_scores_gemma":[0.01001258,0.00437692,0.003511472,0.00001430899,0.00001271263,0.00002409894,0.00001970016,0.0002350649,0.9581256,0.00005002178,0.02315108,0.0004664494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797724,0.01785745,0.0005438091,0.0004486801,0.00006308295,0.0009327601,0.0002958677,0.00004096226,0.00004495417],"genre_scores_gemma":[0.9819732,0.01336774,0.0003658421,0.001543782,0.0003834502,0.0008396156,0.0005161876,0.0001383506,0.0008717738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03468152,"threshold_uncertainty_score":0.9999606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171448116673684,"score_gpt":0.2634713458160522,"score_spread":0.2517568646493154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}