{"id":"W2327930527","doi":"10.1021/acschembio.5b00068","title":"Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Trace Elements in Health","field":"Nursing","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Canada Research Chairs; Howard Hughes Medical Institute","keywords":"Gene isoform; Enzyme; Biochemistry; Cofactor; Chemistry; Biology; Metalloprotein; Isozyme; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716633,0.0003625785,0.0003924585,0.0005786775,0.0001223356,0.0007215446,0.0003917642,0.0004698242,0.000600173],"category_scores_gemma":[0.0007573983,0.0003604679,0.0003245454,0.0003529689,0.0004355268,0.0004202548,0.0004737315,0.0005021328,0.0003563061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216051,"about_ca_system_score_gemma":0.00009429702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001557948,"about_ca_topic_score_gemma":0.0001772893,"domain_scores_codex":[0.9994774,0.00006269558,0.00008979117,0.0001833012,0.0001282982,0.00005838668],"domain_scores_gemma":[0.9991097,0.0002232233,0.0002914299,0.0001368165,0.0001159976,0.000122774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009553137,0.00001068876,0.002637959,0.00002278584,0.000007546728,0.00004383223,0.00003197453,0.00003438782,0.9957937,0.00006170075,0.000009035516,0.001250791],"study_design_scores_gemma":[0.0000140926,0.0002343602,0.0581559,0.00000717938,0.0000326588,0.001689053,0.000113303,0.001218169,0.9368337,0.000416172,0.001269257,0.00001621174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953033,0.0008160975,0.003068066,0.00004003678,0.000005414804,0.00001130704,0.000190741,0.00005635537,0.0005086238],"genre_scores_gemma":[0.9968072,0.0002192337,0.002159769,0.00002221832,0.00000485745,0.00001163095,0.0003773076,0.0000156709,0.0003820766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007215446,"threshold_uncertainty_score":0.002007723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05403624695102556,"score_gpt":0.3352956044112548,"score_spread":0.2812593574602292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}