{"id":"W2327930527","doi":"10.1021/acschembio.5b00068","title":"Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Trace Elements in Health","field":"Nursing","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Canada Research Chairs; Howard Hughes Medical Institute","keywords":"Gene isoform; Enzyme; Biochemistry; Cofactor; Chemistry; Biology; Metalloprotein; Isozyme; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003943726,0.0002023268,0.000475697,0.0000538016,0.00003907144,0.000006962834,0.0003017712,0.0002350633,0.00004735775],"category_scores_gemma":[0.0007617644,0.000148618,0.00008692116,0.0001477612,0.0003695989,0.0001047139,0.0001511233,0.0002794381,0.00003228082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001447544,"about_ca_system_score_gemma":0.00007901981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319189,"about_ca_topic_score_gemma":0.00001848202,"domain_scores_codex":[0.9984731,0.0001311416,0.0003717218,0.0003774681,0.0001687682,0.0004777923],"domain_scores_gemma":[0.9989219,0.0002432836,0.0002269016,0.0003452721,0.00009027969,0.0001723268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007166318,0.0005034117,0.01585904,0.0001127095,0.00012286,0.000002078841,0.0002594945,4.706339e-7,0.9519864,0.001490176,0.001377144,0.02756957],"study_design_scores_gemma":[0.000964815,0.0005389972,0.002257734,0.00001164927,0.00006640924,0.00001485762,0.00007662616,0.00002494787,0.9860215,0.006322817,0.003501115,0.0001985546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962198,0.0002330973,0.00007762957,0.001408321,0.000537737,0.000394388,0.00004983363,0.0001067137,0.0009724923],"genre_scores_gemma":[0.9973904,0.00000286995,0.0021529,0.0001127428,0.0001493378,0.00004152974,0.00006846429,0.00002348162,0.00005819633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03403506,"threshold_uncertainty_score":0.6060466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05403624695102556,"score_gpt":0.3352956044112548,"score_spread":0.2812593574602292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}