{"id":"W2327960993","doi":"10.1038/ni.3433","title":"S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Ottawa; McMaster University; Children's Hospital of Eastern Ontario; McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"IRF3; Transcription factor; Cell biology; TANK-binding kinase 1; Biology; Interferon regulatory factors; Stimulator of interferon genes; Effector; P70-S6 Kinase 1; Sting; Signal transduction; Kinase; PI3K/AKT/mTOR pathway; Genetics; Protein kinase A; Gene; MAP kinase kinase kinase; Innate immune system; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515963,0.0002068168,0.0002911238,0.0001914333,0.000157761,0.000007180952,0.0003463826,0.0009802365,0.0006997708],"category_scores_gemma":[0.0007671355,0.0001158336,0.0001702296,0.0002020215,0.0003418877,0.0002211842,0.0000721722,0.0007619279,0.0001515389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001146679,"about_ca_system_score_gemma":0.00006183165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003947806,"about_ca_topic_score_gemma":0.00001460801,"domain_scores_codex":[0.9984109,0.0005448663,0.0004101683,0.0002605512,0.00004672973,0.000326793],"domain_scores_gemma":[0.998589,0.0005177286,0.0003183429,0.0003940576,0.0001724563,0.000008388992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001133079,0.0000650256,0.0003990993,0.000008823245,0.0002089484,2.826018e-7,0.0003810519,2.785624e-7,0.9846124,0.0006155534,0.0003723059,0.01220317],"study_design_scores_gemma":[0.001202183,0.0002092704,0.05636824,0.000165116,0.00002136921,0.00005932893,0.0001701163,0.000001006967,0.911662,0.00009508513,0.02991748,0.000128794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926832,0.001646784,0.00009858725,0.002004776,0.002772346,0.0002313711,0.00003518858,0.00008734623,0.0004403866],"genre_scores_gemma":[0.9969791,0.0001274508,0.00001001082,0.0001822245,0.00003532113,0.00001502416,0.00003627919,0.00002082738,0.002593729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07295039,"threshold_uncertainty_score":0.7661999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009501375114197146,"score_gpt":0.2411415268125264,"score_spread":0.2316401516983293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}