{"id":"W2327960993","doi":"10.1038/ni.3433","title":"S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Ottawa; McMaster University; Children's Hospital of Eastern Ontario; McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"IRF3; Transcription factor; Cell biology; TANK-binding kinase 1; Biology; Interferon regulatory factors; Stimulator of interferon genes; Effector; P70-S6 Kinase 1; Sting; Signal transduction; Kinase; PI3K/AKT/mTOR pathway; Genetics; Protein kinase A; Gene; MAP kinase kinase kinase; Innate immune system; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993583,0.0003999584,0.0002603969,0.0002752166,0.0004842415,0.0006791885,0.0002959371,0.0003213768,0.004078344],"category_scores_gemma":[0.0002068824,0.0002183574,0.0005193751,0.000170008,0.0004058175,0.0004440816,0.000525975,0.00104623,0.0015362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000883683,"about_ca_system_score_gemma":0.0003790704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005972263,"about_ca_topic_score_gemma":0.001036142,"domain_scores_codex":[0.9997159,0.00004038654,0.00001259058,0.00005423988,0.00005571881,0.0001210308],"domain_scores_gemma":[0.999859,0.00001854502,0.00004380524,0.00001919333,0.00001698442,0.00004244418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004781485,0.00003236032,0.0004455858,0.00003196678,0.000005569443,0.00006318983,0.00001983576,0.00009196345,0.9967548,0.0004203423,0.000196345,0.001459931],"study_design_scores_gemma":[0.00006612712,0.0001296438,0.02561226,0.00001829784,0.00001948393,0.0003097065,0.000136428,0.00406553,0.9652173,0.0005964139,0.003813294,0.00001551508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911762,0.001672913,0.002547806,0.0003270281,0.00009262544,0.00001273249,0.0004452778,0.0001814599,0.003543869],"genre_scores_gemma":[0.9968374,0.0003308748,0.0006672288,0.00005581573,0.00001258168,0.000007028346,0.0004741352,0.00003002145,0.001584867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004078344,"threshold_uncertainty_score":0.01364344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009501375114197146,"score_gpt":0.2411415268125264,"score_spread":0.2316401516983293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}