{"id":"W2328012130","doi":"10.1002/pbc.25984","title":"A Phase 3, Randomized, Double‐Blind, Placebo‐Controlled Study to Determine the Effect of Romiplostim on Health‐Related Quality of Life in Children with Primary Immune Thrombocytopenia and Associated Burden in Their Parents","year":2016,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Romiplostim; Medicine; Placebo; Immune thrombocytopenia; Quality of life (healthcare); Randomized controlled trial; Pediatrics; Clinical endpoint; Physical therapy; Internal medicine; Thrombopoietin; Platelet; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002135877,0.001144042,0.003239624,0.0004744622,0.0006165507,0.0008399648,0.0009904419,0.001776006,0.006232104],"category_scores_gemma":[0.002049798,0.0006827306,0.00151906,0.0004355218,0.001145476,0.0008795417,0.0003064318,0.002399825,0.0006700602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005562177,"about_ca_system_score_gemma":0.001806308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007843617,"about_ca_topic_score_gemma":0.00171017,"domain_scores_codex":[0.9992124,0.0004478724,0.00005262757,0.0001123451,0.00007398484,0.0001007816],"domain_scores_gemma":[0.9987214,0.0004620265,0.0003055938,0.0001150197,0.000104021,0.0002918523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9566309,0.01949742,0.0007093198,0.001179724,0.000760072,0.00008316378,0.00008620493,0.0002132012,0.005113638,0.0001155957,0.0006589053,0.0149519],"study_design_scores_gemma":[0.9335136,0.06455912,0.001114797,0.00002637851,0.0001343224,0.00002424419,0.00001261666,0.0001341699,0.0002170749,0.00003939456,0.0002179527,0.000006230076],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810184,0.004234599,0.001039786,0.000517015,0.0005020478,0.01016096,0.001073919,0.0001592417,0.001294048],"genre_scores_gemma":[0.9669119,0.0033885,0.003821953,0.001716043,0.0004889658,0.02082469,0.0009145788,0.00003380682,0.001899541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006232104,"threshold_uncertainty_score":0.02084851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783214446712209,"score_gpt":0.3098116549389092,"score_spread":0.2919795104717871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}