{"id":"W2328177007","doi":"10.1093/chromsci/48.2.150","title":"Assessment of the Enzymatic Activity and Inhibition using HPFA with a Microreactor, Trypsin, Absorbed on Immobilized Artificial Membrane","year":2010,"lang":"en","type":"article","venue":"Journal of Chromatographic Science","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Benzamidine; Chromatography; Trypsin; Substrate (aquarium); Hydrolysis; PMSF; Microreactor; Immobilized enzyme; Kunitz STI protease inhibitor; Enzyme; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006978442,0.0009854725,0.0005876615,0.0003483782,0.000215387,0.0004562374,0.0005035427,0.000572081,0.0005302497],"category_scores_gemma":[0.0007066766,0.0002979877,0.0003220866,0.0002312574,0.0003668974,0.0005606317,0.0002456553,0.0007351072,0.000371324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506617,"about_ca_system_score_gemma":0.0004311452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090108,"about_ca_topic_score_gemma":0.001274687,"domain_scores_codex":[0.9994343,0.0001133099,0.00004468373,0.0001728934,0.0001717152,0.00006316917],"domain_scores_gemma":[0.9995758,0.000148057,0.0001073432,0.00003478634,0.00008473109,0.00004924015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002229622,0.000005908011,0.0000666487,0.00001631825,0.000003065211,0.000009298977,0.000005924565,0.00000829933,0.999294,0.0000112861,0.00000378896,0.0005530474],"study_design_scores_gemma":[0.000003732463,0.0001948445,0.00164129,0.000002347699,0.00001543335,0.0001287586,0.00001076861,0.0005753099,0.9969677,0.00001174975,0.0004434002,0.000004704679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8723338,0.008526517,0.1168202,0.0002059815,0.0000758559,0.0001108625,0.000308366,0.0004032309,0.001215253],"genre_scores_gemma":[0.8057547,0.006569758,0.1811758,0.000168371,0.00008324807,0.0003144597,0.0007462804,0.00008193297,0.005105458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090108,"threshold_uncertainty_score":0.00369066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086895446707674,"score_gpt":0.2685859046150701,"score_spread":0.2577169501479933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}