{"id":"W2328196102","doi":"10.1021/jp2126366","title":"Distinct Dimerization for Various Alloforms of the Amyloid-Beta Protein: Aβ<sub>1–40</sub>, Aβ<sub>1–42</sub>, and Aβ<sub>1–40</sub>(D23N)","year":2012,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Centre National de la Recherche Scientifique; Institut Universitaire de France; Canada Research Chairs","keywords":"Dimer; Salt bridge; Chemistry; Oligomer; Crystallography; Molecular dynamics; Population; Amyloid (mycology); Protein folding; Energy landscape; Fibril; Biophysics; Stereochemistry; Computational chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268294,0.000286745,0.0001835854,0.0001505031,0.000343537,0.0002340062,0.000258723,0.0003141,0.0008663351],"category_scores_gemma":[0.0003240859,0.00013688,0.0002320658,0.0001830595,0.0002971066,0.0003044652,0.0001772604,0.0003583721,0.00009762581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004194505,"about_ca_system_score_gemma":0.0003201441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002947767,"about_ca_topic_score_gemma":0.003016369,"domain_scores_codex":[0.9999467,0.000009543718,0.000004295885,0.00001506819,0.00001233041,0.00001206862],"domain_scores_gemma":[0.9998975,0.0000310643,0.00002240001,0.00000882596,0.0000171809,0.00002300823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000706889,0.000916476,0.03359493,0.0003905646,0.0002243414,0.0007223141,0.0007334793,0.5632094,0.3732751,0.00859736,0.001239971,0.01638918],"study_design_scores_gemma":[0.0001223953,0.0004933457,0.01750094,0.00001826761,0.00006066662,0.0002390649,0.0002529329,0.9312819,0.0461931,0.002170328,0.001620561,0.00004646115],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975829,0.00009557159,0.001665313,0.00002627322,0.000005067906,0.000009209074,0.00005624245,0.00001963094,0.000539799],"genre_scores_gemma":[0.9966643,0.0001027844,0.002765081,0.0000165834,0.000001224683,0.00001981275,0.0001855896,0.00001231831,0.0002322637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002947767,"threshold_uncertainty_score":0.005861223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430986441816358,"score_gpt":0.2702417217778459,"score_spread":0.2559318573596824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}