{"id":"W2328198526","doi":"10.1016/j.pharmthera.2016.03.003","title":"Emerging therapeutic targets in metastatic progression: A focus on breast cancer","year":2016,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Stem Cell Network; Howard Hughes Medical Institute; Brewster Foundation; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Breast cancer; Metastasis; Metastatic breast cancer; Medicine; Cancer; Stromal cell; Oncology; Cancer research; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005910097,0.000979243,0.001596542,0.001544396,0.0002422019,0.001002215,0.000716834,0.0009464961,0.003988888],"category_scores_gemma":[0.0006767046,0.0002730844,0.0005094536,0.001711251,0.0004990424,0.001195514,0.0007013124,0.002554952,0.001642026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005688811,"about_ca_system_score_gemma":0.0009867145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006332983,"about_ca_topic_score_gemma":0.002566668,"domain_scores_codex":[0.999862,0.000022452,0.00001712586,0.00002965394,0.00004416701,0.00002458843],"domain_scores_gemma":[0.9997489,0.0001073071,0.00003876374,0.000007401366,0.00006461539,0.00003305586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001908301,0.0001242275,0.0001746904,0.01239245,0.0000937514,0.0001841365,0.00003765669,0.0005194784,0.003820445,0.004110889,0.03625919,0.9420922],"study_design_scores_gemma":[0.00008317633,0.0002886456,0.0007904427,0.002997648,0.0002623665,0.001078706,0.00006460782,0.0003214028,0.001306438,0.003198218,0.9895812,0.00002694629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001377495,0.9981882,0.0002346193,0.0003451775,0.0002526453,0.000005344115,0.00002365969,0.00001200547,0.0008005855],"genre_scores_gemma":[0.001038494,0.9974572,0.0002774196,0.0003056669,0.000218577,0.000007376713,0.00003360027,0.000002539595,0.0006590849],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003988888,"threshold_uncertainty_score":0.01334417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0551328506508307,"score_gpt":0.4462391177077469,"score_spread":0.3911062670569162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}