{"id":"W2328257377","doi":"10.1097/fpc.0b013e3283586c04","title":"Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes","year":2012,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"H. Lundbeck A/S; Mylan; Pfizer","keywords":"Candidate gene; Schizophrenia (object-oriented programming); Pharmacogenetics; Single-nucleotide polymorphism; Genetics; Genetic association; Medicine; Multiple comparisons problem; Biology; Gene; Psychiatry; Bioinformatics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000633126,0.0005900984,0.0006559261,0.001202871,0.0003822086,0.0004927623,0.0004202087,0.000546546,0.002451156],"category_scores_gemma":[0.002311036,0.0002735938,0.0006609266,0.001253798,0.000272634,0.0001469223,0.0004506679,0.0003765336,0.0003389223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705269,"about_ca_system_score_gemma":0.0002529725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193853,"about_ca_topic_score_gemma":0.002042531,"domain_scores_codex":[0.9990552,0.0003443042,0.00009027035,0.00023522,0.0001877299,0.00008732072],"domain_scores_gemma":[0.9987471,0.0004076339,0.0005397198,0.0001252368,0.00007679825,0.0001034658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002448919,0.0001388988,0.9018963,0.00008270079,0.001245561,0.001395831,0.0003796875,0.0008904082,0.07401867,0.0002478594,0.0002393321,0.01701581],"study_design_scores_gemma":[0.00007922461,0.0003087252,0.9913085,0.0000142095,0.0003454192,0.00124503,0.0001093295,0.001046128,0.004389929,0.0003150086,0.0008228775,0.00001565483],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989544,0.0001931823,0.000337319,0.00003688595,0.000003964971,0.000005951456,0.0002641713,0.00000576617,0.0001983725],"genre_scores_gemma":[0.9982929,0.000136782,0.0007129066,0.0000324826,0.000006912831,0.00002286474,0.0004130077,0.000008923662,0.0003733276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002451156,"threshold_uncertainty_score":0.00819993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361964462246518,"score_gpt":0.2753900534195028,"score_spread":0.2617704087970377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}