{"id":"W2328352462","doi":"10.1021/jm5005336","title":"The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1<i>R</i>,2<i>S</i>)-2-(3-((<i>E</i>)-4-(((<i>cis</i>)-2,6-Dimethylmorpholino)methyl)styryl)-1<i>H</i>-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"SLAC National Accelerator Laboratory","keywords":"Chemistry; Kinase; Cyclopropane; Stereochemistry; Polo-like kinase; Protein kinase domain; Biochemistry; Cell cycle; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002760344,0.0005629914,0.001024011,0.0001453358,0.0002153047,0.00007256183,0.001201314,0.0004620454,0.00001835336],"category_scores_gemma":[0.001555368,0.00043795,0.0006620543,0.0004067991,0.0007617021,0.00006588645,0.000322278,0.0008585979,0.00000477149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008903,"about_ca_system_score_gemma":0.0006905582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006234839,"about_ca_topic_score_gemma":0.00001156423,"domain_scores_codex":[0.9947363,0.0003459122,0.002393734,0.0006104677,0.001278767,0.0006347946],"domain_scores_gemma":[0.9936736,0.0002498309,0.003470756,0.00106604,0.001186298,0.0003534797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001608141,0.0005294141,0.0004286258,0.0003703575,0.0004438453,0.00003392796,0.0001867145,0.00007144105,0.9888226,0.00002700884,0.001607715,0.005870238],"study_design_scores_gemma":[0.002327323,0.0009606276,0.0007690247,0.0004229853,0.0004442883,0.0004993274,0.0008441976,0.00002888836,0.9829726,0.0002478167,0.01007224,0.0004106484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881982,0.004403654,0.00485036,0.0005764598,0.0009115703,0.0003630021,0.0001156326,0.00001147162,0.0005696858],"genre_scores_gemma":[0.9927343,0.003456949,0.001063712,0.0003910883,0.001472765,0.00001611772,0.0001087261,0.00007999647,0.0006763758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008464524,"threshold_uncertainty_score":0.9998072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331205123937271,"score_gpt":0.2445910552117513,"score_spread":0.238259850087814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}