{"id":"W2328463947","doi":"10.1136/sextrans-2011-050109.143","title":"O4-S1.05 RNA helicases, p72 and p68 and HDAC1 interact with HIV-1 integrase and affect viral replication","year":2011,"lang":"en","type":"article","venue":"Sexually Transmitted Infections","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Integrase; Virology; Viral replication; Integrase inhibitor; Biology; Reverse transcriptase; Virus; RNA; Genetics; Viral load; Gene; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070037,0.0004325805,0.000267977,0.0002233452,0.000287535,0.0004557806,0.0002122181,0.0003836859,0.004345862],"category_scores_gemma":[0.000123072,0.0001333981,0.0003124567,0.0001837649,0.0002325347,0.0002158494,0.0002219133,0.0003249733,0.001089093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004126018,"about_ca_system_score_gemma":0.0002417963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319784,"about_ca_topic_score_gemma":0.001567916,"domain_scores_codex":[0.9998614,0.00001028762,0.000005389694,0.00003884116,0.00003953669,0.0000445965],"domain_scores_gemma":[0.9999378,0.00000681418,0.00002040245,0.000003278785,0.0000104003,0.00002138986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002014003,0.00002691563,0.001284091,0.00009409101,0.000009484846,0.00007352722,0.00002034485,0.00003957413,0.9937709,0.0001087824,0.0001777619,0.004193044],"study_design_scores_gemma":[0.00003110034,0.0003182896,0.0217094,0.0000200247,0.00002873767,0.0007261591,0.00009337006,0.001102485,0.9649082,0.0002148116,0.01083504,0.00001242729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775917,0.009876093,0.004482335,0.0003563965,0.00009259711,0.00007186001,0.001461455,0.0002314607,0.005835949],"genre_scores_gemma":[0.9807636,0.00237488,0.005307828,0.0001480771,0.0000313166,0.0000432468,0.001781194,0.00004583665,0.009504085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004345862,"threshold_uncertainty_score":0.01453835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620351155072859,"score_gpt":0.2599834313761319,"score_spread":0.2437799198254034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}