{"id":"W2328574129","doi":"10.1021/jm300138g","title":"First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeurAxon (Canada)","funders":"","keywords":"Chemistry; Neuropathic pain; Pharmacology; Nitric oxide synthase; Enos; Inhibitory postsynaptic potential; Hyperalgesia; Nitric oxide; Norepinephrine; Internal medicine; Biochemistry; Medicine; Receptor; Nociception","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005665,0.0004716258,0.000305243,0.0001579734,0.0001142881,0.0001820266,0.0004103263,0.0001744545,0.001512924],"category_scores_gemma":[0.00006183619,0.0001106048,0.0002315466,0.0001566764,0.0001408585,0.000168151,0.0001423554,0.0003314783,0.0004532512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024185,"about_ca_system_score_gemma":0.0002905235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007535072,"about_ca_topic_score_gemma":0.002932924,"domain_scores_codex":[0.9999497,0.000006532794,0.000003970235,0.00001044281,0.00001040169,0.00001903762],"domain_scores_gemma":[0.9999591,0.000003104345,0.00001209862,0.000003448758,0.000009816786,0.00001254786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004895943,0.0001134435,0.0004028218,0.0003095599,0.00002842357,0.0002470492,0.00004820196,0.0005088468,0.9786258,0.0006912727,0.0002782339,0.01825674],"study_design_scores_gemma":[0.00008821491,0.003205469,0.002479975,0.00002813925,0.00009950869,0.001127472,0.00005372619,0.0006705662,0.9778191,0.0001536649,0.01424694,0.00002719591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9366882,0.03277267,0.01626696,0.000276449,0.0002020664,0.0002734983,0.001732284,0.0002379901,0.01154985],"genre_scores_gemma":[0.9707029,0.01211725,0.01074012,0.000122841,0.00002321728,0.00006143446,0.0007899823,0.00001833079,0.005423778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512924,"threshold_uncertainty_score":0.005061209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03652680056808819,"score_gpt":0.304082573200171,"score_spread":0.2675557726320827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}