{"id":"W2328625892","doi":"10.1021/acs.analchem.5b02504","title":"Universal Strategy To Engineer Catalytic DNA Hairpin Assemblies for Protein Analysis","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University","keywords":"Chemistry; DNA; Catalysis; Nanotechnology; Computational biology; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188787,0.0002418472,0.0003285414,0.00009041752,0.00005161775,0.00004976935,0.000248023,0.0002336574,0.000004869421],"category_scores_gemma":[0.0003438086,0.0002227878,0.0003142414,0.0006021841,0.00008423041,0.000006650327,0.00009913496,0.0000989362,0.000005642331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006296506,"about_ca_system_score_gemma":0.0001274095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001840962,"about_ca_topic_score_gemma":0.00002118894,"domain_scores_codex":[0.9986063,0.00001606733,0.0002577361,0.0005493757,0.000211458,0.0003590644],"domain_scores_gemma":[0.9987523,0.00001268443,0.00006580237,0.0005032016,0.0003040196,0.000362021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002282963,0.0001466588,0.0004319916,0.00004944614,0.00131157,0.00001322763,0.0000149626,0.001007471,0.9862043,0.0001447708,0.009483166,0.0009640893],"study_design_scores_gemma":[0.0003348354,0.0002402396,0.0000585904,0.00001083343,0.000638984,0.00000478119,0.0001516005,0.004632802,0.9791626,0.0001328587,0.0142307,0.000401215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318419,0.00008947475,0.0619326,0.0006006372,0.00001952159,0.0003313082,0.0001024095,0.0001157287,0.004966444],"genre_scores_gemma":[0.9859424,0.000003476082,0.004819712,0.0001127124,0.000204646,0.00002300313,0.0004723562,0.00002311159,0.008398607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05711289,"threshold_uncertainty_score":0.9085021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186898381885138,"score_gpt":0.2873424164329299,"score_spread":0.2686525782444161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}