{"id":"W2328660396","doi":"10.1097/01.qai.0000397409.60275.47","title":"227 Kinome Profiling of Bovine Leukemia Virus-induced Ovine Leukemia: An Approach for Identifying Altered Signaling Pathways and Drugable Targets in Cancer","year":2011,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Kinome; Leukemia; Biology; Cancer research; Cancer; Phosphorylation; Cell signaling; Cancer cell; Signal transduction; Computational biology; Cell; Cell biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001407622,0.000375532,0.001181778,0.000719456,0.0003260959,0.00002713441,0.0005161312,0.0003086509,0.00004019646],"category_scores_gemma":[0.0001931904,0.0002994717,0.0002630798,0.0004699146,0.0003157581,0.0005584952,0.0001832829,0.000323362,0.000003155734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278789,"about_ca_system_score_gemma":0.0003937037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009297808,"about_ca_topic_score_gemma":0.00001714784,"domain_scores_codex":[0.9970077,0.0002088657,0.001507842,0.0004245254,0.0001387489,0.0007122686],"domain_scores_gemma":[0.9981306,0.0001664213,0.001102036,0.0002938425,0.0002536169,0.00005350687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006404411,0.0002888909,0.004586603,0.000332914,0.0002684695,0.00001805852,0.004464022,0.0001509638,0.987507,0.0001393014,0.0000148518,0.00158849],"study_design_scores_gemma":[0.004017256,0.002285119,0.02107797,0.0003844412,0.0002460713,0.0003579287,0.006718123,0.0002932198,0.9637701,0.0003446162,0.00001938203,0.0004857633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608589,0.0365654,0.0009546992,0.000009837548,0.001004101,0.0004026141,0.00004774216,0.00003419598,0.0001224833],"genre_scores_gemma":[0.9945985,0.000976555,0.004138089,0.00001399351,0.0000513163,0.00003908506,0.00002090919,0.00005032868,0.0001111911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03558885,"threshold_uncertainty_score":0.9999458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06998590241678036,"score_gpt":0.277171518442822,"score_spread":0.2071856160260416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}