{"id":"W2328721578","doi":"10.1016/s0090-9556(24)15121-5","title":"Metabolism and Pharmacokinetics, in the Rat, of (R)-N-(2-Heptyl)Methyl-Propargylamine (R-2HMP), A New Potent Monoamine Oxidase Inhibitor and Antiapoptotic Agent","year":2000,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Pharmacokinetics; Monoamine oxidase; Chemistry; Demethylation; Pharmacology; Metabolism; Oral administration; Monoamine oxidase B; Stereochemistry; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003489842,0.0007501349,0.0005829103,0.0006555807,0.0003611859,0.0005064443,0.0003958691,0.0007220436,0.001432115],"category_scores_gemma":[0.0007062306,0.0007978833,0.0005474398,0.0003973584,0.0007259246,0.001202292,0.0001722526,0.001336606,0.0007155007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007936773,"about_ca_system_score_gemma":0.0009441584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004083973,"about_ca_topic_score_gemma":0.004267189,"domain_scores_codex":[0.9998016,0.00006591371,0.00001009393,0.00004392278,0.00003160247,0.00004687226],"domain_scores_gemma":[0.9993429,0.0001022883,0.0001920824,0.0001021279,0.00006039099,0.0002002573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08012919,0.003302382,0.006503507,0.0002632331,0.0002626856,0.0005102398,0.0004857611,0.002451803,0.8545562,0.001068535,0.001774049,0.04869232],"study_design_scores_gemma":[0.001813879,0.05033443,0.04947684,0.00004872289,0.0007915346,0.001653707,0.0004229497,0.01136424,0.8770649,0.0007707824,0.006098513,0.0001593018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931517,0.002126729,0.002009596,0.0001979596,0.00006195915,0.00004374722,0.0008458061,0.0001593719,0.001403225],"genre_scores_gemma":[0.9887713,0.003106872,0.001869289,0.0001305121,0.00008607428,0.00008305469,0.001189447,0.00008116238,0.004682309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004083973,"threshold_uncertainty_score":0.008120358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03420951576661733,"score_gpt":0.3392879570280054,"score_spread":0.3050784412613881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}