{"id":"W2328721578","doi":"10.1016/s0090-9556(24)15121-5","title":"Metabolism and Pharmacokinetics, in the Rat, of (R)-N-(2-Heptyl)Methyl-Propargylamine (R-2HMP), A New Potent Monoamine Oxidase Inhibitor and Antiapoptotic Agent","year":2000,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Pharmacokinetics; Monoamine oxidase; Chemistry; Demethylation; Pharmacology; Metabolism; Oral administration; Monoamine oxidase B; Stereochemistry; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001166744,0.0004434625,0.0006965869,0.0002379517,0.0002559492,0.00005570462,0.0002222162,0.0002336989,0.0007887947],"category_scores_gemma":[0.0000377799,0.0003392859,0.0001058599,0.0003126608,0.0004466718,0.0002728,0.0000985407,0.0005992803,0.00001460491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504414,"about_ca_system_score_gemma":0.00004635297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002653078,"about_ca_topic_score_gemma":0.00002897628,"domain_scores_codex":[0.9968399,0.001112891,0.0007005092,0.0005691592,0.0002519606,0.0005255675],"domain_scores_gemma":[0.9987516,0.0004093962,0.0002077673,0.0002239255,0.00006042447,0.0003468587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002400256,0.001407224,0.002535539,0.0003086294,0.0003710987,0.0001051471,0.007765781,0.0001974514,0.6461754,0.003360812,0.006937599,0.328435],"study_design_scores_gemma":[0.01838395,0.0003024029,0.2620459,0.000109611,0.003981443,0.0003035572,0.001095232,0.005913407,0.4606116,0.002688463,0.2431093,0.001455256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573532,0.03808001,0.00004480163,0.002443536,0.000564754,0.0008090761,0.000114082,0.00003312932,0.0005574558],"genre_scores_gemma":[0.9740418,0.02205298,0.0002484805,0.002331994,0.0005908008,0.00006486641,0.00006685968,0.00003280626,0.0005694065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3269798,"threshold_uncertainty_score":0.9999059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03420951576661733,"score_gpt":0.3392879570280054,"score_spread":0.3050784412613881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}