{"id":"W2328793728","doi":"10.1074/jbc.m115.711622","title":"Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Periplasmic space; ATP-binding cassette transporter; Biophysics; Membrane; Chemistry; Transporter; Membrane transport protein; Conductance; Conformational change; Chloride channel; Ion channel; Membrane transport; Mutant; Membrane protein; Biochemistry; Biology; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875617,0.0001652881,0.0002236868,0.0001094898,0.0003395807,0.0007321698,0.0002953207,0.0005516425,0.0005329074],"category_scores_gemma":[0.0003668713,0.0001676324,0.0002635326,0.0001064528,0.0005668692,0.0006152203,0.0004729083,0.0006067589,0.0002688535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003894457,"about_ca_system_score_gemma":0.0002600666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003747519,"about_ca_topic_score_gemma":0.0003331638,"domain_scores_codex":[0.9998533,0.00003464361,0.00001662368,0.00003212596,0.00003595611,0.00002735224],"domain_scores_gemma":[0.9998181,0.00003272028,0.00005682845,0.00002974923,0.0000165607,0.00004603486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001750238,0.0000422458,0.001057269,0.00003314209,0.000009735956,0.00037818,0.00009366608,0.0005400793,0.9949759,0.001355819,0.00005457739,0.00128426],"study_design_scores_gemma":[0.0000417557,0.0005746285,0.003101137,0.000009011084,0.00002253615,0.001151262,0.00009475422,0.003094715,0.989086,0.0008940888,0.00189406,0.00003604513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965214,0.0001567785,0.002660718,0.00009942504,0.00001185772,0.000007818782,0.00003566456,0.00005090174,0.0004555152],"genre_scores_gemma":[0.9987669,0.0000529565,0.0008802565,0.0000259974,0.000002308747,0.000004792155,0.00004743501,0.000008294328,0.0002110581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007321698,"threshold_uncertainty_score":0.002825618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05429947691873621,"score_gpt":0.2735803341540415,"score_spread":0.2192808572353053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}