{"id":"W2328989571","doi":"10.1021/ac501588y","title":"Trimethylation Enhancement Using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Carleton University","keywords":"Chemistry; Diazomethane; Glycerophospholipid; Mass spectrometry; Chromatography; Analyte; Sinomenine; Fragmentation (computing); Selected reaction monitoring; Ion; Tandem mass spectrometry; Combinatorial chemistry; Organic chemistry; Phospholipid; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009546775,0.0003880368,0.0008508484,0.0003496798,0.00009008681,0.00002117453,0.0001283218,0.0002826086,0.0003642234],"category_scores_gemma":[0.0001534607,0.0003789398,0.000127197,0.001404251,0.00021558,0.0002438918,0.00006995827,0.0004222513,0.000001063565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004540579,"about_ca_system_score_gemma":0.00004259549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006461989,"about_ca_topic_score_gemma":0.00003103983,"domain_scores_codex":[0.9971814,0.0001365809,0.001007972,0.0007160631,0.0005384798,0.0004194682],"domain_scores_gemma":[0.9980243,0.0004074152,0.0008277282,0.000412111,0.0001937105,0.0001347294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004185507,0.0004506877,0.007948918,0.0003441322,0.0001038601,0.000005141126,0.0001685957,0.00006093167,0.9877644,0.0001390261,6.36439e-7,0.002595096],"study_design_scores_gemma":[0.001073434,0.0002059596,0.007281706,0.0001810174,0.0002027265,0.00001239442,0.00009264056,0.06177234,0.9281598,0.0006677331,0.000003201538,0.0003470799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8941026,0.0001875307,0.1042284,0.00004765153,0.00001551041,0.0002266869,0.00003441199,0.00003661605,0.001120551],"genre_scores_gemma":[0.9959362,0.0002517207,0.003273871,0.000007933328,0.0000843599,0.0000365739,0.0003300888,0.00003286302,0.00004645097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1018335,"threshold_uncertainty_score":0.9998662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174276115014854,"score_gpt":0.2761820537476408,"score_spread":0.2587544422461553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}