{"id":"W2328989571","doi":"10.1021/ac501588y","title":"Trimethylation Enhancement Using Diazomethane (TrEnDi) II: Rapid In-Solution Concomitant Quaternization of Glycerophospholipid Amino Groups and Methylation of Phosphate Groups via Reaction with Diazomethane Significantly Enhances Sensitivity in Mass Spectrometry Analyses via a Fixed, Permanent Positive Charge","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Carleton University","keywords":"Chemistry; Diazomethane; Glycerophospholipid; Mass spectrometry; Chromatography; Analyte; Sinomenine; Fragmentation (computing); Selected reaction monitoring; Ion; Tandem mass spectrometry; Combinatorial chemistry; Organic chemistry; Phospholipid; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003307484,0.0007919386,0.0002282952,0.0002489848,0.0001303925,0.0002087477,0.0003784291,0.0003505226,0.001074326],"category_scores_gemma":[0.000346994,0.0002571187,0.0002391007,0.0001532745,0.0003155954,0.0003185157,0.0003673676,0.0005813382,0.000530374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658703,"about_ca_system_score_gemma":0.0002291009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805212,"about_ca_topic_score_gemma":0.0009073742,"domain_scores_codex":[0.999837,0.00002778576,0.000009253687,0.00005277359,0.00005238568,0.00002065979],"domain_scores_gemma":[0.9998708,0.00003317858,0.00004221333,0.00001533108,0.00002390744,0.00001460257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001451311,0.000002560988,0.00003108799,0.00001557696,0.000002085337,0.00001498885,0.000004371936,0.00001904226,0.9988971,0.00002711571,0.0000106003,0.0009608712],"study_design_scores_gemma":[0.000002939091,0.00004980609,0.0002330602,0.000001212339,0.000004984185,0.00009220184,0.000002970066,0.0002220083,0.9987289,0.0000232887,0.0006357697,0.000002880861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7820313,0.00308288,0.2087307,0.0004138937,0.0001237755,0.0002943679,0.0004109165,0.0008192107,0.004092949],"genre_scores_gemma":[0.8802502,0.003333439,0.111132,0.0002392177,0.00005011048,0.0001600908,0.0004800177,0.0001142891,0.004240667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074326,"threshold_uncertainty_score":0.003593922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174276115014854,"score_gpt":0.2761820537476408,"score_spread":0.2587544422461553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}