{"id":"W2328991709","doi":"10.1158/1538-7445.am2012-4884","title":"Abstract 4884: The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Cisplatin; Ovarian cancer; Cancer research; Cancer; Kinase; CHEK1; Biology; Cancer cell; Dephosphorylation; Phosphatase; DNA damage; Apoptosis; Ovarian carcinoma; Medicine; Internal medicine; Cell cycle; Cell cycle checkpoint; Chemotherapy; Phosphorylation; Cell biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000135,0.0002942757,0.0002734741,0.0002910708,0.00015923,0.0002059043,0.0002357945,0.0002491078,0.002720835],"category_scores_gemma":[0.0001253525,0.0001493699,0.0001846032,0.0002176872,0.0001736974,0.0001113729,0.0001977323,0.0004225155,0.000515661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003357775,"about_ca_system_score_gemma":0.0001949393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008177512,"about_ca_topic_score_gemma":0.000678875,"domain_scores_codex":[0.9998372,0.00002240105,0.00001922292,0.00002678011,0.00005633171,0.00003809824],"domain_scores_gemma":[0.9999282,0.00001661481,0.00001296436,0.00001672584,0.000007986005,0.00001744742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001399369,0.00004291681,0.0002989648,0.00002070289,0.000003159384,0.00003518054,0.000005480751,0.00005411923,0.9984019,0.00005541521,0.00007583425,0.0008662369],"study_design_scores_gemma":[0.00003249079,0.00042239,0.004453913,0.000002648877,0.000008680763,0.0002129046,0.00001210596,0.0008265614,0.9922868,0.00002146965,0.001717655,0.000002406298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958798,0.0006739561,0.0007666411,0.0001228041,0.00004528053,0.00003348975,0.0007164879,0.00007257805,0.001689008],"genre_scores_gemma":[0.9949932,0.0003411013,0.0009358882,0.00004366404,0.000009595276,0.00004549974,0.001131394,0.00001693518,0.002482752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002720835,"threshold_uncertainty_score":0.009102106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05974899658051212,"score_gpt":0.3567264207579343,"score_spread":0.2969774241774222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}