{"id":"W2329003397","doi":"10.1177/095632020701800205","title":"Kinetics of Inhibition of HIV Type 1 Reverse Transcriptase-Bearing NRTI-associated Mutations by Apricitabine Triphosphate","year":2007,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Resistance mutation; Biology; Primer (cosmetics); Nucleotidyltransferase; Reverse-transcriptase inhibitor; Mutation; Molecular biology; Virology; Nucleoside Reverse Transcriptase Inhibitor; Wild type; Nucleoside; Mutant; Chemistry; RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483408,0.0001895398,0.0003738993,0.00004677801,0.00002815268,0.00000449179,0.00005154774,0.0001324922,0.0001927133],"category_scores_gemma":[0.00004000798,0.0001819934,0.0001236532,0.000435296,0.00009901169,0.00005600535,0.00000734888,0.0001189542,0.00000646657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009001033,"about_ca_system_score_gemma":0.00003870852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651575,"about_ca_topic_score_gemma":0.000001313868,"domain_scores_codex":[0.9987999,0.000009166695,0.000473336,0.0002091237,0.0002671042,0.0002413554],"domain_scores_gemma":[0.9993387,0.00003635857,0.0002109718,0.0001700205,0.0001761028,0.00006777133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000330746,0.0008184274,0.01339138,0.0001303506,0.0002018419,0.00001606922,0.0004648134,6.735954e-7,0.9793714,0.00000356846,0.003871163,0.001399575],"study_design_scores_gemma":[0.004215291,0.00009446395,0.003950581,0.0001760415,0.0001189982,0.000003942698,0.00016898,0.00001827345,0.988768,0.00002114393,0.002317532,0.000146745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947629,0.00032043,0.0002954567,0.0006466719,0.00003154546,0.0002101941,0.00005171107,0.00004527667,0.00363579],"genre_scores_gemma":[0.9901114,0.000211191,0.0008546754,0.00009938492,0.00002814091,0.000003134864,0.0006431623,0.00003032485,0.00801866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009440795,"threshold_uncertainty_score":0.7421476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009658679323601324,"score_gpt":0.2477513750349181,"score_spread":0.2380926957113168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}