{"id":"W2329021282","doi":"10.1021/jm2015292","title":"Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Maspin; Antiandrogens; LNCaP; Chemistry; Prostate cancer; Androgen receptor; Antagonist; Cancer research; Apoptosis; Antiandrogen; Pharmacology; Cancer; Internal medicine; Endocrinology; Receptor; Biochemistry; Medicine; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082212,0.00009231841,0.0002720871,0.0000847528,0.0000261209,0.000004444496,0.0000364717,0.00005127711,0.00002797953],"category_scores_gemma":[0.00003477637,0.00006116059,0.00001798183,0.0001308333,0.0001681792,0.0001510968,0.00001492822,0.0002485629,2.956271e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005385061,"about_ca_system_score_gemma":0.0002004899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004741287,"about_ca_topic_score_gemma":0.000004386195,"domain_scores_codex":[0.999262,0.000009667894,0.0002498805,0.0001060866,0.0002507133,0.0001216089],"domain_scores_gemma":[0.9994302,0.00002017928,0.0002348431,0.00005548031,0.0001555472,0.0001037157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001915446,0.0001445467,0.113164,0.0006722571,0.0001374626,0.00007883039,0.003447893,0.000001389798,0.878165,0.000004540634,0.000005195378,0.002263443],"study_design_scores_gemma":[0.003794746,0.0003485757,0.1915592,0.001002652,0.00009687847,0.0007024157,0.002383955,0.00005923281,0.7999667,0.00001703579,0.000009867637,0.00005878965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922085,0.007030447,0.00005955354,0.0003864927,0.00001816613,0.00009585358,0.000005064967,0.000002445642,0.0001934683],"genre_scores_gemma":[0.9960471,0.003437794,0.0003176153,0.00001033546,0.000066703,0.000004551534,0.000001527096,0.000008372061,0.0001059364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07839517,"threshold_uncertainty_score":0.2494057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06686049253920473,"score_gpt":0.3196708128696387,"score_spread":0.2528103203304339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}