{"id":"W2329182709","doi":"10.1021/jo500794v","title":"Rigid 2′,4′-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ribonucleoside; Chemistry; Stereochemistry; RNA polymerase; RNA; Polymerase; Primer (cosmetics); Cytidine; NS5B; Transcription (linguistics); DNA; Molecular biology; Biochemistry; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526612,0.0002273683,0.0001318994,0.000103565,0.0001305899,0.0001916693,0.0001776841,0.0001821202,0.0005777241],"category_scores_gemma":[0.0002566844,0.0001109606,0.0001162871,0.0001233788,0.0001675982,0.0001871134,0.000103326,0.0002176023,0.0001454337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072004,"about_ca_system_score_gemma":0.0001463067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098744,"about_ca_topic_score_gemma":0.001225455,"domain_scores_codex":[0.9999015,0.00002020907,0.000006474774,0.00002406368,0.00002760346,0.00002003993],"domain_scores_gemma":[0.9999096,0.00002075241,0.00002433681,0.00002107011,0.000009850284,0.00001429081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173853,0.00001299642,0.0003356152,0.00003750339,0.000003944047,0.00005369162,0.00004558809,0.00103506,0.9939691,0.0003643211,0.00002361917,0.004001189],"study_design_scores_gemma":[0.00001078468,0.0003403676,0.001113915,0.000003765625,0.000007005809,0.0001061741,0.00001076859,0.001883695,0.9953348,0.00008982851,0.001089016,0.000009889908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923172,0.0006348894,0.005839348,0.00001981358,0.000007000714,0.00001789512,0.0001515737,0.00003458283,0.0009776591],"genre_scores_gemma":[0.9942046,0.0003958277,0.004598829,0.00001566189,0.000003723489,0.00001407113,0.0002280267,0.00001485558,0.0005244585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098744,"threshold_uncertainty_score":0.002184689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002772262427755085,"score_gpt":0.2049052188201456,"score_spread":0.2021329563923905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}