{"id":"W2329182709","doi":"10.1021/jo500794v","title":"Rigid 2′,4′-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ribonucleoside; Chemistry; Stereochemistry; RNA polymerase; RNA; Polymerase; Primer (cosmetics); Cytidine; NS5B; Transcription (linguistics); DNA; Molecular biology; Biochemistry; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004550329,0.0001088539,0.0001531396,0.00002398663,0.0001182532,0.00003460346,0.0002093718,0.00008259065,0.0001511074],"category_scores_gemma":[0.0001194602,0.00007896126,0.00007588764,0.0001316064,0.00008717609,0.00001129854,0.00004252778,0.0001091134,0.000002153358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002956207,"about_ca_system_score_gemma":0.00009256057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001303017,"about_ca_topic_score_gemma":0.00000632662,"domain_scores_codex":[0.999239,0.00004824414,0.0003384546,0.00009751812,0.0001786535,0.00009808082],"domain_scores_gemma":[0.999095,0.00003416229,0.0003976205,0.0002424555,0.000145771,0.00008495503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004628452,0.00002922181,0.0004973237,0.00001348429,0.0002123075,1.700131e-7,0.00005754968,0.00001513086,0.9944416,0.00001192979,0.001882299,0.002792708],"study_design_scores_gemma":[0.0002712714,0.00003828758,0.0008516263,0.00001032194,0.0003060996,0.00004050719,0.0001446304,0.0001510677,0.9920601,0.00008254212,0.005933561,0.0001099698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831509,0.001623253,0.01407281,0.0007234748,0.0000362594,0.0000368748,0.00001101665,0.000003478268,0.0003419241],"genre_scores_gemma":[0.9986036,0.0006124004,0.000241844,0.0001573172,0.0002083763,0.000001986325,0.00003587505,0.000009840387,0.0001287591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154527,"threshold_uncertainty_score":0.3219947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002772262427755085,"score_gpt":0.2049052188201456,"score_spread":0.2021329563923905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}