{"id":"W2329258854","doi":"10.1021/tx400036v","title":"Bisphenol A Activates the Nrf1/2-Antioxidant Response Element Pathway in HEK 293 Cells","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; Carleton University","funders":"","keywords":"Oxidative stress; Antioxidant; HEK 293 cells; Chemistry; Transactivation; Reactive oxygen species; Glutathione; NRF1; Biochemistry; Enzyme; Cell biology; Biology; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004904178,0.0003668338,0.0006284369,0.000318039,0.0004058321,0.0005881215,0.0004990396,0.0004192471,0.002977568],"category_scores_gemma":[0.0002822495,0.0003527983,0.0005226621,0.0006103509,0.0002782407,0.0004432666,0.0003376778,0.001018729,0.001816434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003758085,"about_ca_system_score_gemma":0.0003575159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110016,"about_ca_topic_score_gemma":0.001461209,"domain_scores_codex":[0.9990762,0.000154312,0.0001469809,0.0001819245,0.0003311255,0.0001094108],"domain_scores_gemma":[0.9997745,0.00006574889,0.00003568832,0.00004197916,0.00005885868,0.00002320791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001929643,0.00009051096,0.0002053205,0.0001221091,0.00001370356,0.00008112824,0.00007927491,0.0001514419,0.9971801,0.0002559719,0.0002146506,0.001412818],"study_design_scores_gemma":[0.00004170445,0.0001708355,0.002372266,0.00001156371,0.00002676472,0.0002932503,0.00006686086,0.002930897,0.9844844,0.0001430315,0.009441408,0.00001707701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094839,0.004354611,0.06241191,0.001165972,0.0005753543,0.0004669461,0.01036579,0.0006721918,0.01050329],"genre_scores_gemma":[0.8980698,0.004760846,0.05608912,0.0007213615,0.00009596485,0.0005584725,0.01635156,0.0001653898,0.02318754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977568,"threshold_uncertainty_score":0.009961009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219226124958914,"score_gpt":0.3375128318795005,"score_spread":0.2953205706299114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}