{"id":"W2329287198","doi":"10.1097/ccm.0000000000001376","title":"Effects and Mechanisms by Which Hypercapnic Acidosis Inhibits Sepsis-Induced Canonical Nuclear Factor-κB Signaling in the Lung","year":2015,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Chiesi Farmaceutici","keywords":"Medicine; Acidosis; Hypercapnia; IκBα; Inflammation; Internal medicine; Endocrinology; Biology; NF-κB","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003040727,0.0003921261,0.0003589542,0.0001631402,0.0001837791,0.000400187,0.0003283006,0.0002875789,0.001345713],"category_scores_gemma":[0.0002411364,0.0001325999,0.0003526201,0.0001388509,0.0003972267,0.0004901411,0.0003078279,0.0007157656,0.0001989442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003699709,"about_ca_system_score_gemma":0.0005442057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005476294,"about_ca_topic_score_gemma":0.0009058469,"domain_scores_codex":[0.9997653,0.00005278732,0.00002311976,0.00003415396,0.00006381542,0.00006082044],"domain_scores_gemma":[0.9998307,0.00001508885,0.00006614756,0.00001806009,0.00002442049,0.00004549582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001758738,0.0001448419,0.0005304989,0.0002579054,0.00003655164,0.00008240182,0.00002949436,0.0002095293,0.9929819,0.0001127681,0.0001097106,0.003745493],"study_design_scores_gemma":[0.0001925752,0.003836157,0.02395738,0.0000794691,0.00009349141,0.0004168734,0.0002288678,0.001059585,0.9665291,0.0001728913,0.003415776,0.000017891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781265,0.01604149,0.003648204,0.0004695165,0.0001055884,0.00006742448,0.0003682744,0.00008188935,0.001091112],"genre_scores_gemma":[0.9906645,0.006734837,0.001162441,0.0001640391,0.00004016392,0.00009164524,0.0002728731,0.000009208762,0.0008603824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001345713,"threshold_uncertainty_score":0.004501879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128922703288314,"score_gpt":0.291624427532501,"score_spread":0.2703352004996178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}