{"id":"W2329340366","doi":"10.1021/ar400044k","title":"Exploiting Peptide Nanostructures To Construct Functional Artificial Ion Channels","year":2013,"lang":"en","type":"review","venue":"Accounts of Chemical Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Lipid bilayer; Ion channel; Circular dichroism; Crown ether; Peptide; Bilayer; Transmembrane channels; KcsA potassium channel; Combinatorial chemistry; Nanotechnology; Ion; Materials science; Crystallography; Membrane; Voltage-gated ion channel; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578042,0.0001817954,0.0001441194,0.0001044289,0.00007676319,0.0002513885,0.0001855561,0.0002705893,0.0002689691],"category_scores_gemma":[0.0002787617,0.0001058543,0.0001417068,0.00007573926,0.0001834147,0.0002681781,0.0001961651,0.0003091902,0.0001596041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641905,"about_ca_system_score_gemma":0.00009575416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001262585,"about_ca_topic_score_gemma":0.000179732,"domain_scores_codex":[0.999916,0.00001402663,0.000009983659,0.00001900255,0.00002622454,0.00001482372],"domain_scores_gemma":[0.999894,0.0000303445,0.00002739064,0.00001149943,0.00002078964,0.0000159877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000153343,0.00001180837,0.00006613846,0.00002827201,0.000002726005,0.00003081999,0.00001379614,0.0005525493,0.9974077,0.0002845005,0.00001952528,0.001566845],"study_design_scores_gemma":[0.00001841718,0.0001524392,0.0003861072,0.000004057913,0.000006554148,0.0001010194,0.000009952043,0.004940026,0.9919446,0.0001354969,0.002294393,0.000007101635],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9744707,0.001205381,0.02113831,0.0001317189,0.00006829044,0.00007735634,0.0001371854,0.0001486199,0.002622433],"genre_scores_gemma":[0.9661239,0.0007611115,0.0320412,0.00009106949,0.00001456338,0.00005471796,0.0001236629,0.00002467407,0.0007650547],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0002705893,"threshold_uncertainty_score":0.001191318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.119687215810251,"score_gpt":0.4223797413817265,"score_spread":0.3026925255714754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}