{"id":"W2329426942","doi":"10.1089/scd.2014.0030","title":"iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth","year":2014,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Institute for Clinical and Translational Research, University of Wisconsin, Madison; National Institutes of Health; Waisman Center; FRAXA Research Foundation","keywords":"Fragile X syndrome; FMR1; Biology; Neurite; Forebrain; Induced pluripotent stem cell; Intellectual disability; Phenotype; Neuroscience; Loss function; Reprogramming; Haploinsufficiency; Mutation; Genetics; Fragile x; Gene; In vitro; Central nervous system; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001719513,0.0002608875,0.0002126472,0.00007637316,0.0001068805,0.00005398721,0.0001691224,0.0001314457,0.0000182893],"category_scores_gemma":[0.00001087904,0.0002603662,0.00003922381,0.00007376853,0.00006720215,0.000005197655,0.0002784088,0.0001057566,0.00001912972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001083672,"about_ca_system_score_gemma":0.00009742585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001857748,"about_ca_topic_score_gemma":0.0001949094,"domain_scores_codex":[0.9984742,0.00009605399,0.0003226346,0.0005649035,0.000176805,0.0003653432],"domain_scores_gemma":[0.999531,0.0000280144,0.00007531338,0.0001977882,0.00002342788,0.0001444895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007414948,0.0001787943,0.04999972,0.00006077853,0.00006476423,0.0000140142,0.001458091,0.00009349216,0.9100525,0.00003974908,0.001178223,0.03678577],"study_design_scores_gemma":[0.001861067,0.0001967888,0.3176519,0.0000350446,0.00001001933,0.000004442472,0.000291827,0.00005603462,0.6297509,0.000121489,0.04941352,0.0006069023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976774,0.0002609028,0.0004362711,0.0000738835,0.0002078936,0.0002568734,0.00002347864,0.00001305135,0.001050199],"genre_scores_gemma":[0.9969319,0.0001714486,0.001561598,0.0009518698,0.00003027347,0.00003668524,0.0001238973,0.00003370201,0.0001585922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2803015,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177933580195785,"score_gpt":0.2117575482586875,"score_spread":0.1999782124567296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}