{"id":"W2329426942","doi":"10.1089/scd.2014.0030","title":"iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth","year":2014,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Institute for Clinical and Translational Research, University of Wisconsin, Madison; National Institutes of Health; Waisman Center; FRAXA Research Foundation","keywords":"Fragile X syndrome; FMR1; Biology; Neurite; Forebrain; Induced pluripotent stem cell; Intellectual disability; Phenotype; Neuroscience; Loss function; Reprogramming; Haploinsufficiency; Mutation; Genetics; Fragile x; Gene; In vitro; Central nervous system; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405107,0.0002807975,0.0002461364,0.0002709443,0.0002161888,0.0002278833,0.0001959895,0.0002891394,0.001906952],"category_scores_gemma":[0.00009164715,0.0001080918,0.0002385078,0.0001365294,0.00024953,0.0001034719,0.000248348,0.0004808613,0.001112094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193168,"about_ca_system_score_gemma":0.0001771984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163981,"about_ca_topic_score_gemma":0.00199479,"domain_scores_codex":[0.9998951,0.000005931352,0.00001982735,0.00002831377,0.00003617845,0.00001458831],"domain_scores_gemma":[0.9999156,0.00001617947,0.00001462809,0.00001762553,0.00001040076,0.00002556164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000053828,0.00002532991,0.0009800406,0.00004203238,0.000009777655,0.001011359,0.0001083164,0.0001097862,0.9934062,0.0002556133,0.0002047119,0.003792852],"study_design_scores_gemma":[0.00001767715,0.0002327495,0.02706096,0.00003268583,0.00003269194,0.004887711,0.0001547143,0.0007322116,0.9546886,0.000210784,0.01193847,0.00001077184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978807,0.0009990726,0.007716977,0.0001106369,0.0000605984,0.0001004202,0.004489372,0.0002413581,0.007474559],"genre_scores_gemma":[0.9714339,0.001452588,0.00964056,0.0001091506,0.00001475429,0.0001328718,0.006041222,0.0001141552,0.01106074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906952,"threshold_uncertainty_score":0.006379426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177933580195785,"score_gpt":0.2117575482586875,"score_spread":0.1999782124567296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}