{"id":"W2329450342","doi":"10.1016/j.jalz.2015.07.268","title":"O3‐06‐02: Venular degeneration in the pathogenesis of Alzheimer's disease","year":2015,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Cerebral amyloid angiopathy; Mural cell; Pathology; Venule; Microcirculation; Arteriole; Cognitive decline; Pathogenesis; Senile plaques; Angiopathy; Alzheimer's disease; Anatomy; Neuroscience; Medicine; Biology; Vascular smooth muscle; Disease; Dementia; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001880533,0.0003474046,0.0001898743,0.0003089065,0.0002006888,0.0003693529,0.0002475997,0.0005548616,0.001024266],"category_scores_gemma":[0.00007541228,0.00009322795,0.0001256822,0.000144728,0.0002829946,0.0002266945,0.0002266067,0.0004855403,0.0002678546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313955,"about_ca_system_score_gemma":0.0001835188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005027082,"about_ca_topic_score_gemma":0.0005578639,"domain_scores_codex":[0.99993,0.0000123388,0.000004708176,0.00001900642,0.00001591527,0.00001796102],"domain_scores_gemma":[0.9999421,0.000003351065,0.00001989133,0.000003927413,0.000008717236,0.00002204204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001318195,0.0001465314,0.007300609,0.0001522365,0.00002092516,0.001059374,0.00007987922,0.00008669004,0.9757726,0.0004952876,0.0003092071,0.01325856],"study_design_scores_gemma":[0.0003276552,0.003232535,0.3947566,0.0001608466,0.000204851,0.01656031,0.000485831,0.002718252,0.556052,0.003989059,0.02146443,0.00004758536],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886051,0.007825123,0.001058715,0.0002315053,0.000030176,0.00001875956,0.0001122226,0.00005188514,0.002066461],"genre_scores_gemma":[0.9937074,0.00298483,0.0008926055,0.0001172249,0.0000376756,0.00001880462,0.0001309868,0.00001044198,0.00210004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024266,"threshold_uncertainty_score":0.003426552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08549351791182583,"score_gpt":0.2867559372191523,"score_spread":0.2012624193073264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}