{"id":"W2329467994","doi":"10.1124/mol.112.083618","title":"Transport Function and Transcriptional Regulation of a Liver-Enriched Human Organic Anion Transporting Polypeptide 2B1 Transcriptional Start Site Variant","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Organic anion-transporting polypeptide; Function (biology); Transcriptional regulation; Chemistry; Biology; Biochemistry; Cell biology; Computational biology; Gene; Gene expression; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408086,0.0003506523,0.0002997149,0.0002728376,0.0002621551,0.0003682386,0.0002512761,0.0003917957,0.002915703],"category_scores_gemma":[0.0002611455,0.0001806155,0.0004459118,0.0002218344,0.0004110013,0.00009842107,0.0002047617,0.0007406157,0.0009980828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005415505,"about_ca_system_score_gemma":0.0003355361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003016133,"about_ca_topic_score_gemma":0.003357397,"domain_scores_codex":[0.9997169,0.00007084369,0.00002737479,0.00008200155,0.00004525422,0.00005753771],"domain_scores_gemma":[0.9997335,0.00009009797,0.00004737815,0.00002696536,0.00003250581,0.00006947878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005633488,0.00005662666,0.0007724922,0.00002036263,0.00001190373,0.0001115352,0.00003543903,0.0001567836,0.9969864,0.0002420211,0.0001002226,0.0009428435],"study_design_scores_gemma":[0.0001576978,0.0005530735,0.02728007,0.00003521903,0.0000777847,0.001114835,0.0001909461,0.004433145,0.9609364,0.0002398558,0.004940235,0.00004068638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953319,0.0004117509,0.002518816,0.0001429479,0.00005778652,0.00001729802,0.0009366158,0.00005206953,0.0005307593],"genre_scores_gemma":[0.9959487,0.000103574,0.000991807,0.00008679463,0.00001563425,0.00001283074,0.00179049,0.00007562368,0.0009745098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003016133,"threshold_uncertainty_score":0.009754002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027248794856844,"score_gpt":0.2338629767093959,"score_spread":0.2235904887608275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}