{"id":"W2329477786","doi":"10.1158/1538-7445.am2012-1352","title":"Abstract 1352: Shp2 is required for CML initiation and maintenance","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Dasatinib; Cancer research; Tyrosine kinase; Imatinib; Bosutinib; Stem cell; Myeloid leukemia; Bone marrow; Imatinib mesylate; Haematopoiesis; Medicine; Biology; Immunology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141385,0.0005011265,0.0002274811,0.0003437723,0.0003126006,0.0004140318,0.0003795242,0.0004840834,0.004858061],"category_scores_gemma":[0.0001387848,0.0001802065,0.0003094017,0.0002005853,0.0002686393,0.0002005245,0.0005012159,0.0008785433,0.001979389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004687463,"about_ca_system_score_gemma":0.0003178141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000981545,"about_ca_topic_score_gemma":0.0014083,"domain_scores_codex":[0.9997645,0.00001707826,0.00002182927,0.00005852589,0.00009834977,0.00003972906],"domain_scores_gemma":[0.9998035,0.00002441405,0.0000536909,0.00001570117,0.00001933794,0.00008345284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007666183,0.00001903952,0.0002991867,0.00003108773,0.000004815874,0.0001813827,0.000009327938,0.00003866496,0.9982945,0.0001400311,0.0002040778,0.0007013048],"study_design_scores_gemma":[0.00005843239,0.0001508425,0.025278,0.00002057266,0.00003028193,0.001590497,0.00006258325,0.002085917,0.9535358,0.0001746298,0.01699416,0.00001836718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714256,0.002446507,0.009570587,0.0005048463,0.0002219657,0.0001005009,0.007906894,0.0006469567,0.007176092],"genre_scores_gemma":[0.9824562,0.0004204995,0.002081386,0.0002073951,0.00002881257,0.00006663993,0.006551419,0.0001388305,0.008048832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004858061,"threshold_uncertainty_score":0.0162518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1621364712561549,"score_gpt":0.4530184521059848,"score_spread":0.2908819808498299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}