{"id":"W2329619353","doi":"10.1097/spc.0b013e328362ffef","title":"The changing landscape in metastatic castration-resistant prostate cancer","year":2013,"lang":"en","type":"review","venue":"Current Opinion in Supportive and Palliative Care","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Enzalutamide; Cabazitaxel; Medicine; Prostate cancer; Cabozantinib; Abiraterone acetate; Oncology; Docetaxel; Disease; Androgen receptor; Internal medicine; Cancer; Pharmacology; Androgen deprivation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345593,0.0004019225,0.001029682,0.0003915902,0.0001413744,0.00007569272,0.0001006645,0.00009175409,0.00009003955],"category_scores_gemma":[0.00006263919,0.0002251918,0.0001712193,0.0006497227,0.0001359813,0.00008924636,0.00007959091,0.0006009462,0.00001584318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992766,"about_ca_system_score_gemma":0.0009374217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004674027,"about_ca_topic_score_gemma":0.00008205854,"domain_scores_codex":[0.9977895,0.0002171461,0.0006467428,0.0004836684,0.0003138279,0.0005490885],"domain_scores_gemma":[0.9988715,0.0002412419,0.0002994789,0.0001922865,0.0002570747,0.0001384244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001021947,0.00006958482,0.01506867,0.03602668,0.000179918,0.0000200004,0.006402931,5.13939e-7,3.347974e-7,0.0001074393,0.0006899484,0.9413318],"study_design_scores_gemma":[0.001590903,0.0002154906,0.00397173,0.04452456,0.000207769,0.000002751648,0.00641433,0.00001459082,0.000002426983,0.00003501113,0.9427018,0.0003186902],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004230253,0.9946638,0.000001447865,0.0001301978,0.000839969,0.00339852,0.0004494371,0.00001074519,0.00008281698],"genre_scores_gemma":[0.0004769652,0.9944698,0.000010155,0.000005654953,0.0001775261,0.003016263,0.00147722,0.0000337773,0.0003326157],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9420118,"threshold_uncertainty_score":0.9183055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1974814507013539,"score_gpt":0.480525015493028,"score_spread":0.2830435647916741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}