{"id":"W2329649329","doi":"10.1021/bc300314u","title":"Biodegradable and Nontoxic Nanogels as Nonviral Gene Delivery Systems","year":2012,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Gene delivery; Cationic polymerization; Raft; Nanogel; Ethyleneimine; DNA condensation; Chain transfer; Polymerization; DNA; Biophysics; Nanotechnology; Transfection; Gene; Polymer; Polymer chemistry; Drug delivery; Biochemistry; Radical polymerization; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001651885,0.0002744836,0.0002060161,0.0000217362,0.0001081182,0.00006578806,0.0002140021,0.0002998463,0.00006391831],"category_scores_gemma":[0.00002720664,0.0002595901,0.00009262715,0.00005874475,0.0001260946,0.00001719826,0.0001728611,0.0001010131,0.0001169693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331601,"about_ca_system_score_gemma":0.00006397433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001103934,"about_ca_topic_score_gemma":0.000002037695,"domain_scores_codex":[0.9986679,0.00002602906,0.0002508558,0.0004103304,0.0001366837,0.0005081887],"domain_scores_gemma":[0.9991392,0.000007856655,0.00009509589,0.0004200378,0.00007552946,0.0002622434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006099015,0.00005651189,0.003584986,0.00006717315,0.00007018559,0.000004837062,0.00002855734,0.000002353303,0.9936295,0.000009394243,0.002055246,0.0004303089],"study_design_scores_gemma":[0.0003819708,0.00008841851,0.0004371782,0.00002714247,0.00002846689,0.0001735865,0.0001588233,0.00001844657,0.9653475,0.000006967893,0.03298374,0.0003477923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803503,0.01530304,0.0000410799,0.00003538244,0.0002803528,0.0001479463,0.0000563566,0.00002622259,0.0037593],"genre_scores_gemma":[0.9914064,0.00118817,0.0001347967,0.0002112424,0.0007633825,0.00004097464,0.0001843305,0.00003167701,0.00603904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03092849,"threshold_uncertainty_score":0.9999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017549304739678,"score_gpt":0.2231949967532025,"score_spread":0.2130195037058057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}