{"id":"W2329649329","doi":"10.1021/bc300314u","title":"Biodegradable and Nontoxic Nanogels as Nonviral Gene Delivery Systems","year":2012,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Gene delivery; Cationic polymerization; Raft; Nanogel; Ethyleneimine; DNA condensation; Chain transfer; Polymerization; DNA; Biophysics; Nanotechnology; Transfection; Gene; Polymer; Polymer chemistry; Drug delivery; Biochemistry; Radical polymerization; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003854554,0.0003736446,0.0001875174,0.0002682191,0.0001000148,0.000376728,0.0002595239,0.0004288761,0.0005467896],"category_scores_gemma":[0.0003351648,0.0001874709,0.0001563487,0.0001165814,0.0003831752,0.0004988334,0.0002524735,0.0003717173,0.0002721577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004222635,"about_ca_system_score_gemma":0.0002773915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759221,"about_ca_topic_score_gemma":0.0005952258,"domain_scores_codex":[0.9997872,0.00005082983,0.00001380471,0.00003278836,0.00008865591,0.00002670507],"domain_scores_gemma":[0.9998548,0.00003587037,0.00003966912,0.00001092899,0.00003093951,0.00002764232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001451069,0.000006410162,0.00002613397,0.00004572252,0.000002010728,0.00003075822,0.00001318518,0.0001396905,0.9977751,0.0003267107,0.00002494744,0.00159482],"study_design_scores_gemma":[0.000008637252,0.0001315716,0.0002291545,0.000009417299,0.000006280014,0.0001370825,0.00001210137,0.0004937553,0.9954288,0.000154898,0.003382299,0.000006004662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8997779,0.02621755,0.06784804,0.0006617777,0.0001870101,0.0002039686,0.0002877049,0.0003404208,0.004475616],"genre_scores_gemma":[0.9452046,0.007249629,0.03973062,0.000319148,0.00004150545,0.0001669455,0.0002138849,0.00009991254,0.006973673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005467896,"threshold_uncertainty_score":0.003063798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017549304739678,"score_gpt":0.2231949967532025,"score_spread":0.2130195037058057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}