{"id":"W2329651704","doi":"10.1021/ac4009429","title":"Electrochemical Enzyme-Linked Immunosorbent Assay Featuring Proximal Reagent Generation: Detection of Human Immunodeficiency Virus Antibodies in Clinical Samples","year":2013,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Detection limit; Immunoassay; Antibody; Gp41; Reagent; Alkaline phosphatase; Chromatography; Antigen; Primary and secondary antibodies; Virology; Enzyme; Molecular biology; Biochemistry; Immunology; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002057704,0.001227172,0.0009458191,0.0009673969,0.0001936157,0.0007476243,0.00133868,0.002325753,0.0005957777],"category_scores_gemma":[0.00226049,0.0005252666,0.0004379932,0.0006953544,0.0004523493,0.000487888,0.0006170362,0.001256059,0.0008364238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056437,"about_ca_system_score_gemma":0.0003506655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002387672,"about_ca_topic_score_gemma":0.0004912161,"domain_scores_codex":[0.9969429,0.0009715791,0.0001809101,0.0005108347,0.00127491,0.0001187618],"domain_scores_gemma":[0.9990067,0.0004739853,0.0001400795,0.000063539,0.0002396643,0.00007617056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002052103,0.0002347131,0.00359033,0.0004544898,0.00008214288,0.0003085013,0.00007901577,0.0003616718,0.9623739,0.0002731872,0.0006381975,0.03139868],"study_design_scores_gemma":[0.00009402436,0.001306119,0.005886979,0.00005677426,0.0001151356,0.004499094,0.00003690984,0.007411373,0.9720871,0.0003688136,0.008080747,0.00005688743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3553361,0.04217023,0.5894821,0.001374017,0.001213147,0.002027831,0.001230999,0.002352422,0.004813076],"genre_scores_gemma":[0.4919241,0.01130634,0.4885055,0.001401783,0.000414403,0.001030798,0.0009148738,0.00004384326,0.004458405],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002325753,"threshold_uncertainty_score":0.01088232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366816953426839,"score_gpt":0.3123205951307712,"score_spread":0.2886524255965028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}